Towards simulation of germinal matrix hemorrhage as a complication of premature birth

Renée Lampe, Varvara Turova, Tobias Blumenstein, Ana Alves-Pinto

Cerebral Palsy and Children Neuro-Orthopedics Unit, Orthopedic Department, Clinic “Rechts der Isar”, Technical University of Munich, Munich, Germany.

DOI: 10.4236/ojog.2013.39A008                

Abstract

The germinal matrix being an accumulation of immature blood vessels in the premature infant brain is known to be the main cause of the intracranial hemorrhage. To investigate the injuring mechanism to the blood vessels of the germinal matrix, a modeling scenario that consists of three basic steps is proposed. First, the cerebral blood flow that depends on autoregulation, CO₂ reactivity, and variations of intracranial pressure is modeled. Second, the chaotic blood vessel network of the germinal matrix is generated, and blood pressures in the vessels of this network are computed dependent on the outcome of the first step. In the third step, the pressures computed on the second step are used in finite element simulations of separate blood vessels of the germinal matrix to detect critical values for vessels impairment.

Keywords

Cerebral Palsy; Germinal Matrix Hemorrhage; Injuring Factors; Mathematical Model; Computer Simulation

Conflicts of Interest

The authors declare no conflicts of interest.

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