Efferocytosis in Retinoblastoma


Retinoblastoma has varied presentations. As age advances in retinoblastoma, the undifferentiated tumour is the common appearance. Apoptosis in retinoblastoma in an untreated case can give us a clue about the tumour biology. Efferocytosis in intraocular tumour is a new concept which was seen in an enucleated eyeball specimen in a 4-year-old boy. Effective efferocytosis can be conceptualized for new pharmacodynamics application for anti-cancer drugs. We present a rare case of retinoblastoma with efferocytosis in retinal pigment epithelium and interesting apoptotic changes.

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D. Das, H. Bhattacharjee, K. Bhattacharjee, P. Tahiliani, P. Bhattacharyya, M. Barman, S. Barthakur, P. Deka, A. Deka and R. Paul, "Efferocytosis in Retinoblastoma," Journal of Cancer Therapy, Vol. 4 No. 9, 2013, pp. 1443-1447. doi: 10.4236/jct.2013.49172.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] C. L. Shields, A. Mashayekhi, H. Demirci, A. T. Meadows and J. A. Shields, “Practical Approach to Management of Retinoblastoma,” Archives of Ophthalmology, Vol. 22, No. 5, 2004, pp. 729-735. http://dx.doi.org/10.1001/archopht.122.5.729
[2] R. C. Eagle Jr., “High-Risk Features and Tumour Differentiation in Retinoblastoma: A Retrospective Histopathologic Study,” Archives of Pathology & Laboratory Medicine, Vol. 133, 2009, pp. 1203-1209.
[3] A. H. Wellie, J. F. R. Kerr and A. R. Currie, “Cell Death: The Significance of Apoptosis,” International Review of Cytology, Vol. 68, 1980, pp. 251-306. http://dx.doi.org/10.1016/S0074-7696(08)62312-8
[4] R. S. Scott, E. J. Mcmohan, S. M. Pop, E. A. Reep, R. Caricchio, P. L. Cohen, H. S. Earp and G. K. Matsunshine, “Phagocytosis and Clearance of Apoptotic Cells Is Mediated by MER,” Nature, Vol. 411, No. 6834, 2001, pp. 207-211. http://dx.doi.org/10.1038/35075603
[5] A. H. De Cathelineau and P. H. Henson, “The Final Step in Programmed Cell Death: Phagocytes Carry Apoptotic Cells to the Grave,” Essays in Biochemistry, Vol. 39, 2003, pp. 105-117.
[6] R. W. Vandivier, P. M. Henson and I. S. Douglas, “Burring the Dead: The Impact of Failed Apoptotic Cell Removal (Efferocytosis) on Chronic Inflammatory Lung Disease,” Chest, Vol. 129, No. 6, 2006, pp. 1673-1682. http://dx.doi.org/10.1378/chest.129.6.1673
[7] S. J. Garalei, K. A. McPhillips, S. C. Frasch, et al., “Cell Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through Transactivation of LRP on Phagocyte,” Cell, Vol. 123, No. 2, 2005, pp. 321-334. http://dx.doi.org/10.1016/j.cell.2005.08.032
[8] M. H. Cesan, K. Pegan, A. Spes and B. Turk, “Lysosomal Pathways to Cell Death and Their Therapeutic Application,” Experimental Cell Research, Vol. 318, No. 11, 2012, pp. 1245-1251.
[9] J. S. Lee, Y. J. Kim, C. L. Kim and G. M. Lee, “Differential Induction of Autophagy in Caspase 3/7 Down Regulating and Bcl-2 Overexpressing Recombinant CHO Cells Subjected to Sodium Butyrate Treatment,” Journal of Biotechnology, Vol. 161, No. 1, 2012, pp. 34-41. http://dx.doi.org/10.1016/ j.jbiotec.2012.05.011

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