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A Comparative Study of Thyroid Hormone and Lipid Status of Patient with and without Diabetes in Adults

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DOI: 10.4236/ojemd.2013.32017    3,621 Downloads   7,452 Views   Citations

ABSTRACT

Introduction: Lipid and thyroid function abnormalities are common in IDDM and NIDDM. Very few studies have addressed this issue in Bangladesh though Bangladeshi population is very much susceptible to patient with diabetes. Aims: To study on lipid profile and thyroid function in IDDM and NIDDM and the effect of glycemic control on it. Patients and Methods: This was a retrospective study carried out in the Dept. of Endocrinology, BIRDEM, Dhaka, Bangladesh during the period of January, 2012 to May, 2012. In this study, population consisted of 120 subjects (Age between 40 - 72 years; and Sex matched) divided into two groups: patient with diabetes 60 subjects (male-30, female-30) and patient without diabetes 60 subjects (male-30, female-30). Plasma glucose, HbA1c and serum lipids were measured by enzymatic method. Thyroid hormones were measured by a Chemiluminescent Micro particle Immunoassay (CMIA).Results: The statistical significance was evaluated by Student’s t-test, Correlation-Coefficient test. All Values are given as mean ± SD. The level of serum TSH in patient with diabetes (3.43 ± 2.71) was significantly (p < 0.05) increased compared to patient without diabetes subjects (1.98 ± 1.72). TSH levels were positively correlated with fasting plasma glucose (r = 0.240, p < 0.05), serum cholesterol (r = 0.290, p < 0.020) and triglyceride concentration (r = 0.246, p < 0.05). On the other hand, free T4 levels were inversely correlated with postprandial blood glucose (r =0.256, p < 0.046). Conclusions: It may be concluded that the lipid and thyroid function abnormalities with others socio-demographic and biophysical risk factors were more common in patient with diabetes cases rather than patient without diabetes cases. Therefore, further prospective studies with larger number of patients are required to strengthen the observations of the present study.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

H. Saha, H. Khan, B. Sarkar, S. Khan, N. Sana, A. Sugawara and S. Choudhury, "A Comparative Study of Thyroid Hormone and Lipid Status of Patient with and without Diabetes in Adults," Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 2, 2013, pp. 113-119. doi: 10.4236/ojemd.2013.32017.

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