Daptomycin, Methicillin Resistant Staphylococcus hominis Catheter-Related Bacteraemia in a Hemodialysis Patient


We report a case of a haemodialysis patient that presented a catheter-related bacteraemia caused by a Coagulase negative Staphylococcus. With the utilization of molecular biology techniques the bacterial isolate recovered from catheter was surprisingly identified as S. hominis by sequencing of the 16S ribosomal gene. The S. hominis isolate, which is not often associated with infections in dialysis patients, was resistant to methicillin, being mecA positive, and to daptomycin. The patient was successfully treated with vancomycin together with the catheter retirement.

Share and Cite:

M. Macía-Heras, J. Donate-Correa, J. Alcoba-Flórez, G. Pulido-Reyes, E. Martín-Núñez, J. Martín-Padrón and S. Méndez-Álvarez, "Daptomycin, Methicillin Resistant Staphylococcus hominis Catheter-Related Bacteraemia in a Hemodialysis Patient," Open Journal of Medical Microbiology, Vol. 3 No. 1, 2013, pp. 53-55. doi: 10.4236/ojmm.2013.31008.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] G. A. Beathard and A. Urbanes, “Infections Associated with Tunnelled Haemodialysis Catheters,” Seminars in Dialysis, Vol. 21, No. 6, 2008, pp. 528-538. doi:10.1111/j.1525-139X.2008.00497.x
[2] S. Pastan, M. Soucie and W. M. McClellan, “Vascular Access and Increase Risk of Death among Haemodialysis Patients,” Kidney International, Vol. 62, 2002, pp. 620-626. doi:10.1046/j.1523-1755.2002.00460.x
[3] T. Lee, J. Barker and M. Allon, “Tunnelled Catheter in Haemodialysis Patients: Reasons and Subsequent Outcomes,” American Journal of Kidney Diseases, Vol. 46, No. 3, 2005, pp. 501-508. doi:10.1053/j.ajkd.2005.05.024
[4] A. Copca-álvarez, M. A. Cabrera-Suarez, G. Pulido, J. Alcoba-Florez, M. Morales and S. Mendez-Alvarez, “Coagulase Negative Staphylococcus Causes Catheter Associated Bacteraemia in a Patient with Esophagus Adecarcinome,” Journal of Cancer Therapy, Vol. 3, 2012, pp. 627-629. doi:10.4236/jct.2012.35080
[5] S. Méndez-Alvarez and E. Pérez-Roth, “Multiplex PCR in Clinical Microbiology,” Enfermedades Infecciosas y Microbiología Clínica, Vol. 22, 2004, pp. 183-191. doi:10.1157/13058027
[6] E. Pérez-Roth, F. Claverie-Martín, N. Batista, A. Moreno and S. Méndez-Alvarez, “Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus Clinical Isolates in a Spanish Hospital. Co-Application of Multiplex PCR Assay and Conventional Microbiology Methods,” Diagnostic Microbiology & Infectious Disease, Vol. 43, No. 2, 2002, pp. 123-128. doi:10.1016/S0732-8893(02)00388-7
[7] S. J. Vandecasteele, J. R. Boelaert and A. S. De Vriese, “Staphylococcus aureus Infections in Hemodialysis: What a Nephrologist Should Know,” Clinical Journal of the American Society of Nephrology, Vol. 4, No. 8, 2009, pp. 1388-1400. doi:10.2215/CJN.01590309
[8] J. Donate-Correa, J. Alcoba-Flórez and S. Méndez-álvarez, “New Staphylococcus aureus Genetic Cluster Associated with Infectious Osteomyelitis,” International Microbiology, Vol. 14, No. 1, 2011, pp. 33-39.
[9] H. F. Wertheim, D. C. Melles, M. C. Vos, W. van Leeuwen, A. van Belkum, H. A. Verbrugh and J. L. Nouwen, “The Role of Nasal Carriage in Staphylococcus aureus Infections,” The Lancet Infectious Diseases, Vol. 5, No. 12, 2005, pp. 751-762. doi:10.1016/S1473-3099(05)70295-4
[10] I. L. Camargo, H. M. Neoh, L. Cui and K. Hiramatsu, “Serial Daptomycin Selection Generates DaptomycinNonsusceptible Staphylococcus aureus Strains with a Heterogeneous Vancomycin Intermediate Phenotype,” Antimicrobial Agents and Chemotherapy, Vol. 52, No. 12, 2008, pp. 4289-4299. doi:10.1128/AAC.00417-08
[11] P. A. Moise, D. North, J. N. Steenbergen and G. Sakoulas, “Susceptibility Relationship between Vancomycin and Daptomycin in Staphylococcus aureus: Facts and Assumptions,” The Lancet Infectious Diseases, Vol. 9, No. 10, 2009, pp. 617-624. doi:10.1016/S1473-3099(09)70200-2
[12] A. Mangili, I. Bica, R. Snydman and D. H. Hamer, “Daptomycin-Resistant Methicillin-Resistant Staphylococcus aureus Bacteremia,” Clinical Infectious Diseases, Vol. 40, No. 7, 2005, pp. 1058-1060. doi:10.1086/428616
[13] D. J. Skiest, “Treatment Failure Resulting from Resistance of Staphylococcus aureus to Daptomycin,” Journal of Clinical Microbiology, Vol. 44, No. 2, 2006, pp. 655-656. doi:10.1128/JCM.44.2.655-656.2006
[14] G. Sakoulas, J. Alder, C. Thauvin, R. C. Moellering and G. M. Eliopolous, “Induction of Daptomycin Heterogenous Susceptibility in Staphylococcus aureus by Exposure to Vancomycin,” Antimicrobial Agents and Chemotherapy, Vol. 50, No. 4, 2006, pp. 1581-1585. doi:10.1128/AAC.50.4.1581-1585.2006

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.