Isolation and Characterization of S-Enantiomer in Montelukast

Vijaya Lakshmi Maddala, Kishore Kumar Kakumani, Kameswara Rao Chimalakonda, Srinivasulu Polisetty, P. C. Ray

Inogent Laboratories Pvt Ltd., IDA-Nacharam, Hyderabad, India.
Jawaharlal Nehru Technological University Hyderabad, India.

DOI: 10.4236/ajac.2013.41008                

Abstract

A simple and rapid Supercritical Fluid Chromatography (SFC) Method has been developed to isolate and characterize the S-Isomer of Montelukast by using normal phase Amylose based AS-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbon dioxide (CO₂) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated S-Isomer was characterized by using FT-IR, ESI-MS, HPLC and 1H NMR. The purity of isolated S-Isomer is about 98%.

Keywords

(S)-Isomer; Montelukast; Supercritical Fluid Chromatography (SFC)

Conflicts of Interest

The authors declare no conflicts of interest.

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