Neuroplasticity and Positive Psychology in Clinical Practice: A Review for Combined Benefits


Research on using positive psychological perspectives to drive brain plasticity in a positive direction is increasingly encouraging and empowering for clinicians and clients. Increased lifespan with neuroplastic gains was found by Diamond in lab rats when they were held and spoken to. Improvements in brain chemistry, architecture and performance associated with lifestyle choices are now being documented in humans with increasing frequency of reports. Positive psychology can strengthen this trend toward increases in wellbeing by using this evolving research for motivation to increase healthy lifestyle choices, for reinforcement of successive approximation toward these goals and for the many gains associated with greater happiness.

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Shaffer, J. (2012). Neuroplasticity and Positive Psychology in Clinical Practice: A Review for Combined Benefits. Psychology, 3, 1110-1115. doi: 10.4236/psych.2012.312A164.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Abuhamden, S., & Csikszentmihalyi, M. (2012) The importance of challenge for the enjoyment of intrinsically motivated, goal-directed activities. Personality and Social Psychology Bulletin, 38, 317-330. doi:10.1177/0146167211427147
[2] Anderson-Hanley, C., Arciero, P. J., Brickman, A. M., Nimon, J. P., Okuma, N., Westen, S. C., Merz, M. E., Pence, B. D., Woods, J. A., Kramer, A. F., & Zimmerman, E. A. (2012). Exergaming and older adult cognition: A cluster randomized clinical trial. American Journal of Preventive Medicine, 42, 109-119. doi:10.1016/j.amepre.2011.10.016
[3] Angevaren, M., Aufdemkampe, G., Verhaar, H. J. J., Aleman, A., & Vanhees, L. (2008). Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. The Chochrane Collaboration.
[4] Antonuccio, D. L., W. G. Danton, G.Y. DeNelsky, R. Greenberg, & J. S. Gordon. (1999). Raising Questions about Antidepressants. Psychotherapy and Psychosomatics, 68, 3-14. doi:10.1159/000012304
[5] Audiffren, M., Tomporowski, P. & Zagrodnik, J. (2008). Acute aerobic exercise and information processing: Energizing motor processes during a choice reaction time task. Acta Psychologica, 129, 410-419. doi:10.1016/j.actpsy.2008.09.006
[6] Ball, K. K., Berch, D. B., Helmers, K. F., Jobe, J. B., Leveck, M. D., Mariske, M., Morris, J. N., Rebok, G. W., Smith, D. M., Tennstedt, S. L., Unverzagt, F. W., & Willis, S. L. (2002). Effects of cognitive training interventions with older adults: A randomized controlled trial. JAMA, 288, 2271-2281. doi:10.1001/jama.288.18.2271
[7] Beck, A. T. (2006). How an anomalous finding led to a new system of psychotherapy. Nature Medicine, 12, 1139-1141. doi:10.1038/nm1006-1139
[8] Begley, S. (2007). Train your mind change your brain: How a new science reveals our extraordinary potential to transform ourselves. New York: Ballantine Books.
[9] Berry, A. S., Zanto, T. P., Clapp, W. C., Hardy, J. L., Delahunt, P. B., Mahncke, H. W., & Gazzaley, A.. (2010). The influence of perceptual training on working memory in older adults. PLoS ONE, 5, e11537. doi:10.1371/journal.pone.0011537
[10] Burns, D. D. (1992). Feeling good: The new mood therapy. New York: Avon.
[11] Burns, D. D. (1999). The feeling good handbook. New York: Plume.
[12] Colcombe, S., & Kramer, A. F. (2003). Fitness effects on cognitive functioning of older adults: A meta-analytic study. Psychological Science, 14, 125-130. doi:10.1111/1467-9280.t01-1-01430
[13] Cramer, S. C., Sur, M., Dobkin, B. H., O’Brien, C., Sanger, T., D., Trojanowski,, J. Q., Rumsey, J. M., Hicks, R., Cameron, J., Chen, D., Chen, W. G., Cohen, L. G., deCharms, C., Duffy, C. J., Eden, G. F., Fetz, E. E., Filart, R., Freund, M., Grant, S. J., Haber, S., Kalivas, P. W., Kolb, B., Kramer, A. F., Lynch, M., Mayberg, H., McQuillen, P. S., Nitkin, R., Pascual-Leone, A., Reuter-Lorenz, P. C., Schiff, N., Sharma, A., Shekim, L., Stryker, M., Sullivan, E. V., & Vinogradov., S. (2011). Harnessing neuroplasticity for clinical applications. Brain. 134, 1591-1609. doi:10.1093/brain/awr039
[14] Csikszentmihalyi, M. (1997). Finding flow: The psychology of engagement with everyday life. New York: Basic Books.
[15] Csikszentmihalyi, M. (2003). Good business: Leadership, flow and the making of meaning. New York: Penguin Books.
[16] Davidson, R. J., & Begley, S. (2012). The emotional life of your brain: How its unique patterns affect the way you think, feel, and live, and how you can change them. New York: Hudson Street Press.
[17] Davidson, R., Kabat-Zinn. J., Schumacher, J., Rosenkranz, M., Muller, D, Santorelli, S., Urbanowski, F., Harrington, A., Bonus, K., & Sheridan, J. (2003). Alterations in brain and immune function produced by mindfulness meditation. Psychosomatic Medicine, 65, 564 570. doi:10.1097/01.PSY.0000077505.67574.E3
[18] Davidson, R. J., & Lutz, A. (2008). Buddha’s brain: Neuroplasticity and meditation. IEEE Signal Processing Magazine, 25, 176-174. doi:10.1109/MSP.2008.4431873
[19] Diamond, M. C. (1988). Enriching heredity: The impact of the environment on the anatomy of the brain. New York: The Free Press.
[20] Diamond, M. C., & Hopson, J. (1998). Magic trees of the mind: How to nurture your child’s intelligence, creativity, and healthy emotions from birth through adolescence. New York: Plume.
[21] Diamond, M. C., Johnson, R., & Ingham, C. (1971). Brain plasticity induced by environment and pregnancy. International Journal of Neuroscience, 2, 171-178. doi:10.3109/00207457109146999
[22] Diamond, M., Johnson, R, Protti, A., Ott, C., & Kajisa L. (1984). Plasticity in the 904-day-old male rat cerebral cortex. Experimental Neurology, 87, 309-317. doi:10.1016/0014-4886(85)90221-3
[23] Diamond, M. C., Scheibel, A., Murphy Jr., G., & Harvey, T. (1985). On the brain of a scientist: Albert Einstein. Experimental Neurology, 88, 198-204. doi:10.1016/0014-4886(85)90123-2
[24] Edwards, J. D., Myers , C., Ross, L. A., Roenker, D. L., Cissell, G. M., McLaughlin, A. M., & Ball, K. K. (2009). The longitudinal impact of cognitive speed of processing training on driving mobility. The Gerontologist, 49, 485-494. doi:10.1093/geront/gnp042
[25] Duckworth, A. L., Steen, T. A., & Seligman, M. E. P. (2005). Positive psychology in clinical practice. Annual Reviews of Clinical Psychology, 1, 629-651. doi:10.1146/annurev.clinpsy.1.102803.144154
[26] Ellis, A. (2005). Why I (really) became a therapist. Journal of Clinical Psychology, 61, 945-948. doi:10.1002/jclp.20166
[27] Ellis, A. (1987). The impossibility of achieving consistently good mental health. American Psychologist, 42, 364-375. doi:10.1037/0003-066X.42.4.364
[28] Ellis, A, & Harper, R. (1975). A new guide to rational living. Englewood Cliffs, NJ: Prentice-Hall.
[29] Eriksson, P., Perfilieva, E., Bj?rk-Eriksson, T., Alborn, A., Nordborg, C., Peterson, D., & Gage, F. H. (1998). Neurogenesis in the adult human hippocampus. Nature America, Inc.
[30] Eyler, L. T., Sherzai, A., Kaup, A. R., &. Jeste, D.V. (2011). A review of functional brain imaging correlates of successful cognitive aging. Biological Psychiatry, 70, 115-122. doi:10.1016/j.biopsych.2010.12.032
[31] Flynn, J. R. (1984). The mean IQ of Americans: Massive gains 1932 to 1978. Psychological Bulletin, 95, 29-51. doi:10.1037/0033-2909.95.1.29
[32] Flynn, J. R. (1987). Massive IQ gains in 14 nations: What IQ tests really measure. Psychological Bulletin, 101, 171-191. doi:10.1037/0033-2909.101.2.171
[33] Gage, F. (2002). Neurogenesis in the adult brain. The Journal of Neuroscience, 22, 612-613.
[34] Goh, J. O., & Park, D. C. (2009). Neuroplasticity and cognitive aging: The scaffolding theory of aging and cognition. Restorative Neurology and Neuroscience, 27, 391-403.
[35] Goldapple, K., Segal, Z., Garson, C., Lau, M., Bieling, P., Kennedy, S., & Mayberg, H. (2004). Modulation of cortico-limbic pathways in major depression: Treatment-specific effects of cognitive behavioral therapy. Archives of General Psychiatry, 61, 34-41. doi:10.1001/archpsyc.61.1.34
[36] Goleman, D. (2006). Social intelligence: The new science of human relationships. New York: Bantam.
[37] Guzman-Marin, R., & McGinty, D. (2006). Sleep deprivation suppresses adult neurogenesis: Clues to the role of sleep in brain plasticity. Sleep and Biological Rhythms, 4, 27-34. doi:10.1111/j.1479-8425.2006.00203.x
[38] Gregg, J., Pace-Schott, E., Stickgold, R., & Otto, M. (2004). Cognitive behavior therapy and parmacotherapy for insomnia: A randomized controlled trial and direct comparison. Archives of Internal Medicine, 164, 1888-1896. doi:10.1001/archinte.164.17.1888
[39] Jessberger, S., & Gage, F. H. (2008). Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychology & Aging, 23, 684-691. doi:10.1037/a0014188
[40] Jobe, J. B., Smith, D. M., Ball, K. K., Tennstedt, S. L., Marsiske, M., Morris, J. N., Helmers, K. F., Leveck, M. D., & Kleinman, K. (2001). ACTIVE: A cognitive intervention trial to promote independence in older adults. Controlled Clinical Trials, 22, 453-479. doi:10.1016/S0197-2456(01)00139-8
[41] Kempermann, G., Gast, D., & Gage, F. H. (2002). Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Annals of Neurology, 52, 135-143. doi:10.1002/ana.10262
[42] Kohman, R. A., & Rhodes, J. S. (2012). Neurogenesis, inflammation and behavior. Brain, Behavior, and Immunity, 27, 22-32. doi:10.1016/j.bbi.2012.09.003.
[43] Lojovich, J. M. (2010). The relationship between aerobic exercise and cognition: Is movement medicinal? Journal of Head Trauma Rehabilitation, 25, 184-192. doi:10.1097/HTR.0b013e3181dc78cd
[44] Mahncke, H., Bronstone, A., & Michael, M. (2006). Brain plasticity and functional losses in the aged: scientific bases for a novel intervention. Progress in Brain Research, 157, 81-109. doi:10.1016/S0079-6123(06)57006-2
[45] Mahncke, H., Connor, B., Appelman, J., Ahsanuddin, O., Hardy, J., Joyce, N., Boniske, T., Atkins, S., & Merzenich. M. (2006a). Memory enhancement in healthy older adults using a brain plasticity based training program: A randomized, controlled study. Proceedings of the National Academy of Science USA, 103, 12523-12528. doi:10.1073/pnas.0605194103
[46] Malkasian, D., & Diamond, M. C. (1971). The effect of environmental manipulation on the morphology of the neonatal rat brain. International Journal of Neuroscience, 2, 161-170. doi:10.3109/00207457109146998
[47] Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007). An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proceedings of the National Academy of Sciences of the USA, 104, 5638-5643. doi:10.1073/pnas.0611721104
[48] Rabipour, S., & Raz, A. (2012). Training the brain: Fact and fad in cognitive and behavioral remediation. Brain and Cognition, 79, 159 179. doi:10.1016/j.bandc.2012.02.006
[49] Rosano, C., Marsland, A. L., & Gianaros, P. J. (2012). Maintaining brain health by monitoring inflammatory processes: A mechanism to promote successful aging. Aging and Disease, 3, 16-33.
[50] Sapolsky, R. M. (2004). Why zebras don’t get ulcers: The acclaimed guide to stress, stress-related diseases, and coping (3rd ed.). New York: Henry Holt.
[51] Sartori, A. C., Vance, D. E., Slater, L. Z., & Crowe, M. (2012). The impact of inflammation on cognitive function in older adults: Implications for healthcare practice and research. Journal of Neuroscience Nursing, 44, 206-217. doi:10.1097/JNN.0b013e3182527690
[52] Seligman, M. E. P. (2002). Authentic happiness: Using the new positive psychology to realize your potential for lasting fulfillment. New York: Free Press.
[53] Seligman, M. E. P., & Csikszentmihalyi, M. (2000). Positive psychology: an introduction. American Psychologist, 55, 5-14. doi:10.1037/0003-066X.55.1.5
[54] Seligman, M. E. P, Rashid, T., & Parks, A. C. (2006). Positive psychotherapy. American Psychologist, 61, 774-788. doi:10.1037/0003-066X.61.8.774
[55] Seligman, M. E. P., Steen, T. A., Park, N., & Peterson, C. (2005). Positive psychology progress: Empirical validation of interventions. American Psychologist, 60, 410-421. doi:10.1037/0003-066X.60.5.410
[56] Sheline Y., Sanghavi, M., Mintun, M., & Gado, M. (1999). Depression but not age predicts hippocampal volume loss in medically healthy women with recurrent depression. Journal of Neuroscience, 19, 5034-5043.
[57] Snyder, J., Glover, L., Sanzone, K., Kamhi, F., & Cameron, H. (2009). The effects of exercise and stress on the survival and maturation of adult-generated granule cells. Hippocampus, 19, 898-906. doi:10.1002/hipo.20552
[58] Smith, G. E., Housen, P., Yaffe, K., Ruff, R., Kennison, R. F., Mahncke, H. W. et al. (2009). A cognitive training program based on principles of brain plasticity: Results from the improvement in memory with plasticity-based adaptive cognitive training (IMPACT) study. Journal of the American Geriatrics Society, 57, 594-603. doi:10.1111/j.1532-5415.2008.02167.x
[59] Stickgold, R. (2005). Sleep-dependent memory consolidation. Nature, 437, 1272-1278. doi:10.1038/nature04286
[60] Tang, Y.-Y., Lu, Q., Fan, M., Yang, Y., & Posner, M. I. (2012). Mechanisms of white matter changes induced by meditation. Proceedings of the National Academy of Sciences, 109, 10570-10574. doi:10.1073/pnas.1207817109
[61] Uylings, H. B. M., Kuypers, K., Diamond, M. C., & Veltman, W. A. M. (1978). The effects of differential environments on plasticity of cortical pyramidal neurons in adult rats. Experimental Neurology, 68, 158-170.
[62] Wagner, U., Gais, S., Halder, H., Veriger, R., & Born, J. (2004). Sleep inspires insight. Nature, 427, 352-355. doi:10.1038/nature02223
[63] Wolinsky, F. D., Vander Weg, M. W., Martin, R., Frederick, W., Unverzagt, F. W., Ball, K. K., Jones, R. N., & Tennstedt, S. L. (2009). The ACTIVE cognitive training interventions and the onset of and recovery from suspected clinical Depression. Journal of Gerontology, 64A, 468-472. doi:10.1093/gerona/gln044
[64] Zhou, X., & Merzenich, M. M. (2009). Developmentally degraded cortical temporal processing restored by training. Nature Neuroscience, 12, 26-28. doi:10.1038/nn.2239
[65] Zhu, B., Dong, Y., Xu, Z., Gompf, H. S., Ward, S. A. P., Xue, Z., Miao, C, Zhang, Y., Chamberlin, N. L., & Xie. Z. (2012). Sleep disturbance induces neuroinflammation and impairment of learning and memory. Neurobiology of Disease, 19, 898-906.
[66] Zucconi, G. G., Cipriani, S., Balgkouranidou, I., & Scattoni, R. (2006). “One night” sleep deprivation stimulates hippocampal neurogenesis. Brain Research Bulletin, 69, 375-381. doi:10.1016/j.brainresbull.2006.01.009

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