Biomarkers Expression in Cervical Cancer and High Grade Squamous Intraepithelial Lesions

Ostojich Marcela, Gimenez Liliana, Gianni Sergio, Alvarez Ana, Marino Lina, De Dios Diana, Jasnis Maria Adela

Departament of Gynecology, Institute of Oncology Angel H Roffo, University of Buenos Aires, Argentina.
Department of Clinical Oncology, Institute of Oncology Angel H Roffo, University of Buenos Aires, Argentina.
Department of Immunobiology, Institute of Oncology Angel H Roffo, University of Buenos Aires, Argentina..
Department of Pathology, Institute of Oncology Angel H Roffo, University of Buenos Aires, Argentina.

DOI: 10.4236/jct.2012.36139                

Abstract

Objectives: The finding of new prognostic factors in human cervix cancer is necessary to improve present conventional treatments. The aim of the present study was to determine the expression and evaluate the prognostic value of hypoxia-inducible factor-1(HIF-1α), vascular endothelial growth factor (VEGF) and eritropoyetin receptor (EpoR) in cervix cancer stages IIA-IIB and in preinvasive high grade squamous intraepithelial lesions (HSIL) Methods: The study included 70 patients with cervix cancer, FIGO stages IIA-IIB, 28 patients with HSIL and normal cervix (n = 28). HIF-1α, VEGF and EpoR expression were analyzed in tissue samples by immunohistochemistry using commercial antibodies. Expression and overexpression of the tumor markers were quantified according to German Immunoreactive Score. Results: HIF-1α, EpoR and VEGF overexpression was detected in 30%, 37% and 51% of cancer patients respectively. Patients with HSIL showed enhanced expression only of EpoR and VEGF (39.2% and 71.4%) while VEGF was overexpressed in 21% of the specimen. No correlation was found between VEGF and EpoR with disease-free overall survival (OS), tumor recurrences or prognostic factors. Only overexpression of HIF-1 was associated with less median survival measured up to 24 months, unless it was not maintained a long time. Conclusion: Although any of the markers could be considered as independent prognostic factor for cervix cancer patients, our data showed a significant increase in their expression from the premalignant lesion up to the invasive stages of tumor progression.

Keywords

Prognostic Marker; Cervical Cancer; Intraepithelial Lesion; HIF-1α, VEGF; EpoR

Conflicts of Interest

The authors declare no conflicts of interest.

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