Off-Pump CABG for Mulitvessel Coronary Artery Disease-Safe Incorporation into Surgical Practice

Abstract

Introduction: Since its revival two decades ago development of the surgical technique, along with evidence and clinical outcomes of off-pump coronary artery bypass surgery (OPCAB) were brought into focus. Methods: We report a single surgeon, single center experience of the first 37 consecutive patients undergoing off-pump surgery. Patients were selected for OPCAB (study group) individually and matched retrospectively to a control group of 113 patients performed over an identical time frame. Data were retrieved from a hospital data base (TOMCAT). Results: Mean Logistic European System of Cardiac Operative Risk Stratification (EuroSCORE) was slightly higher in the off-pump group (3.8% versus 2.9%). One patient died during the study and this was in the off-pump CAB group (OPCAB-30 day mortality 2.7%). Operating time was slightly shorter in the off-pump group (3 hours 28 minutes versus 3 hours 49 minutes, p = 0.15). After exclusion of outliers, total hospital stay was significantly shorter for off-pump cases (mean 6.8 days versus 8.37 days), while Intensive Care Unit (ICU) stay (1.2 versus 1.4 days) and ventilation time were only slightly shorter (9.35 hours versus 10.6 hours) for off-pump cases. Chest tube drainage was significantly lower in the off-pump group (484 ml versus 744 ml, p = 0.04) with correspondingly slightly lower transfusion requirements and significantly increased discharge haemoglobin concentrations in OPCAB. There was one cerebrovascular accident (CVA) in the off-pump group and none in the on-pump group. Conclusion: In this study we show short term outcomes for introduction of off-pump into surgical technique. Length of ICU stay, ventilation times, chest tube drainage, transfusion re0 quirements and pre-discharge haemoglobin concentration all appeared superior in the off pump group. The off-pump technique was safely introduced into the surgeon`s service with relatively little mortality. Experience of surgeon was considered advantageous for fast adaption of the technique. However, numbers were too small to make strong inferences. With practice more patients should benefit from the technique.

Share and Cite:

C. Nesselmann, S. Aftab, M. Chandran and F. Sutherland, "Off-Pump CABG for Mulitvessel Coronary Artery Disease-Safe Incorporation into Surgical Practice," Open Journal of Thoracic Surgery, Vol. 2 No. 3, 2012, pp. 78-86. doi: 10.4236/ojts.2012.23016.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] B.J. Hindman, Emboli, inflammation, and CNS impairment: an overview, Heart Surg Forum 5 (2002), pp. 249-253.
[2] J.R. Pepper, NICE guidance for off-pump CABG: keep the pump primed, Heart 97, pp. 1728-1730.
[3] B. Bridgewater, R. Kinsman, P. Walton, J. Gummert and A.P. Kappetein, The 4th European Association for Cardio-Thoracic Surgery adult cardiac surgery database report, Interact Cardiovasc Thorac Surg 12, pp. 4-5. http://dx.doi.org/10.1510/icvts.2010.251744
[4] V.H. Thourani and R.A. Guyton, Graft Patency Following Off-Pump Coronary Artery Bypass Surgery, Circulation.
[5] H.K. Song, R.J. Petersen, E. Sharoni, R.A. Guyton and J.D. Puskas, Safe evolution towards routine off-pump coronary artery bypass: negotiating the learning curve, Eur. J. Cardiothorac. Surg. 24 (2003), pp. 947-952. doi:10.1016/S1010-7940(03)00616-X
[6] G.J. Murphy, C.A. Rogers, M. Caputo and G.D. Angelini, Acquiring proficiency in off-pump surgery: traversing the learning curve, reproducibility, and quality control, Ann. Thorac. Surg. 80 (2005), pp. 1965-1970. http:// dx .doi.org/10.1016/j.athoracsur.2005.03.037
[7] A. Kourliouros and T. Athanasiou, Decision making in off-pump coronary artery bypass surgery: where does conversion fit in?, Heart.
[8] J. Puskas, D. Cheng, J. Knight, G. Angelini, D. Decannier, A. Diegeler, et al., Off-Pump versus Conventional Coronary Artery Bypass Grafting: A Meta-Analysis and Consensus Statement From The 2004 ISMICS Consensus Conference, Innovations (Phila) 1 (2005), pp. 3-27.
[9] D. van Dijk, M. Spoor, R. Hijman, H.M. Nathoe, C. Borst, E.W. Jansen, et al., Cognitive and cardiac outcomes 5 years after off-pump vs on-pump coronary artery bypass graft surgery, JAMA 297 (2007), pp. 701-708. doi:10.1001/jama.297.7.701
[10] B. Hattler, J.C. Messenger, A.L. Shroyer, J.F. Collins, S.J. Haugen, J.A. Garcia, et al., Off-Pump Coronary Artery Bypass Surgery is Associated with Worse Arterial and Saphenous Vein Graft Patency and Less Effective Revascularization: Results From the Veterans Affairs Randomized On/Off Bypass (ROOBY) Trial, Circulation.
[11] A.L. Shroyer, F.L. Grover, B. Hattler, J.F. Collins, G.O. McDonald, E. Kozora, et al., On-pump versus off-pump coronaryartery bypass surgery, N Engl J Med 361 (2009), pp. 1827-1837. http://dx.doi.org/10.1056/NEJMo a0902 905
[12] A.S. Ramadan, C. Stefanidis, W. N'Gatchou, B. El Oumeiri, J.L. Jansens, J.M. De Smet, et al., Five years follow-up after Y-graft arterial revascularization: on pump versus off pump; prospective clinical trial, Interact Cardiovasc Thorac Surg 10, pp. 423-427. http:// dx.doi.org/10.1510/icvts.2009.206458
[13] G.D. Angelini, L. Culliford, D.K. Smith, M.C. Hamilton, G.J. Murphy, R. Ascione, et al., Effects of on- and off-pump coronary artery surgery on graft patency, survival, and healthrelated quality of life: long-term follow-up of 2 randomized controlled trials, J Thorac Cardiovasc Surg 137 (2009), pp. 295-303. doi:10.1016/j.jtcvs.2008.09.046
[14] Y. Abu-Omar and D.P. Taggart, The present status of off-pump coronary artery bypass grafting, Eur. J. Cardiothorac. Surg. 36 (2009), pp. 312-321. doi:10.1016/j.ejcts.2009.03.025
[15] D.N. Wijeysundera, W.S. Beattie, G. Djaiani, V. Rao, M.A. Borger, K. Karkouti, et al., Off-pump coronary artery surgery for reducing mortality and morbidity: metaanalysis of randomized and observational studies, J Am Coll Cardiol 46 (2005), pp. 872-882. doi:10.1016/j.jacc.2005.05.064
[16] J.D. Puskas, F.H. Edwards, P.A. Pappas, S. O'Brien, E.D. Peterson, P. Kilgo, et al., Off-pump techniques benefit men and women and narrow the disparity in mortality after coronary bypass grafting, Ann Thorac Surg 84 (2007), pp. 1447-1454; discussion 1454-1446.
[17] N.C. Patel, N.U. Patel, D.F. Loulmet, J.C. McCabe and V.A. Subramanian, Emergency conversion to cardiopul-monary bypass during attempted off-pump revascularization results in increased morbidity and mortality, J Thorac Cardiovasc Surg 128 (2004), pp. 655-661. doi:10.1016/j.jtcvs.2004.04.043
[18] D. Mukherjee, K. Ahmed, K. Baig, V.M. Patel, A. Darzi and T. Athanasiou, Conversion and safety in off-pump coronary artery bypass: a system failure that needs reemphasis, Ann Thorac Surg 91, pp. 630-639. http://dx.doi.org/10.1016/j.athoracsur.2010.10.031
[19] A. Hovakimyan, V. Manukyan, S. Ghazaryan, M. Saghatelyan, L. Abrahamyan and H. Hovaguimian, Predictors of emergency conversion to on-pump during off-pump coronary surgery, Asian Cardiovasc Thorac Ann 16 (2008), pp. 226-230.
[20] A. Vivacqua, C.G. Koch, A.M. Yousuf, E.R. Nowicki, P.L. Houghtaling, E.H. Blackstone, et al., Morbidity of bleeding after cardiac surgery: is it blood transfusion, re-operation for bleeding, or both?, Ann. Thorac. Surg. 91, pp. 1780-1790. http://dx.doi.org/10.1016/j.athoracsur.2011.03.105
[21] S.G. Nair, Atrial fibrillation after cardiac surgery, Ann Card Anaesth 13, pp. 196-205. http://dx.doi.org/10.4103/ 0971-9784.69047
[22] M.F. El-Chami, P. Kilgo, V. Thourani, O.M. Lattouf, D.B. Delurgio, R.A. Guyton, et al., New-onset atrial fibrillation predicts long-term mortality after coronary artery bypass graft, J Am Coll Cardiol 55, pp. 1370-1376. http://dx.doi.org/10.1016/j.jacc.2009.10.058
[23] W. Hueb, N.H. Lopes, A.C. Pereira, A.C. Hueb, P.R. Soares, D. Favarato, et al., Five-year follow-up of a randomized comparison between off-pump and on-pump stable multivessel coronary artery bypass grafting. The MASS III Trial, Circulation 122, pp. S48-52. doi:10.1161/CIRCULATIONAHA.109.924258
[24] J. Puskas, MD, D. Cheng, MD, J. Knight, MD, G. Angelini, MD, D. DeCannier, MD, A. Diegeler, MD, et al., Off-Pump versus Conventional Coronary Artery Bypass Grafting: A Meta-Analysis and Consensus Statement From The 2004 ISMICS Consensus Conference, Innovations 1 (2005).
[25] A. Sedrakyan, A.W. Wu, A. Parashar, E.B. Bass and T. Treasure, Off-pump surgery is associated with reduced occurrence of stroke and other morbidity as compared with traditional coronary artery bypass grafting: a meta-analysis of systematically reviewed trials, Stroke 37 (2006), pp. 2759-2769. http://dx.doi.org/10.1161/01.STR. 0000 245081.52877.f2
[26] J.D. Puskas, W.H. Williams, P.G. Duke, J.R. Staples, K.E. Glas, J.J. Marshall, et al., Off-pump coronary artery by-pass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting, J Thorac Cardiovasc Surg 125 (2003), pp. 797-808. doi:10.1067/mtc.2003.324
[27] M.E. Brizzio, A. Zapolanski, R.E. Shaw, J.S. Sperling and B.P. Mindich, Stroke-related mortality in coronary surgery is reduced by the off-pump approach, Ann. Thorac. Surg. 89, pp. 19-23. http://dx.doi.org/10.1016/ j.athoracsur.2009.07.076
[28] S.J. Hoff, Off-pump coronary artery bypass: techniques, pitfalls, and results, Semin Thorac Cardiovasc Surg 21 (2009), pp. 213-223. http://dx.doi.org/10.1053/j.semtcvs. 2009.09.002
[29] W.B. Halbersma, S.C. Arrigoni, G. Mecozzi, J.G. Grand-jean, A.P. Kappetein, J. van der Palen, et al., Four-year outcome of OPCAB no-touch with total arterial Y-graft: making the best treatment a daily practice, Ann. Thorac. Surg. 88 (2009), pp. 796-801. http://dx.doi.org/10.1016 / j.athoracsur.2009.04.104
[30] M.Y. Emmert, B. Seifert, M. Wilhelm, J. Grunenfelder, V. Falk and S.P. Salzberg, Aortic no-touch technique makes the difference in off-pump coronary artery bypass grafting, J Thorac Cardiovasc Surg.
[31] B.W. Lytle, Evolving technology: recognition and opportunity, Ann Thorac Surg 71 (2001), p. 1409. doi:10.1016/S0003-4975(01)02538-3

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.