The Serological Survey for Human Cysticercosis Prevalence in Mbulu District, Tanzania

DOI: 10.4236/aid.2012.23009   PDF   HTML     3,407 Downloads   6,522 Views   Citations


Human cysticercosis, a zoonotic disease due to Taeniasolium, is of the highly debilitating and stigmatizing neglected tropical diseases due to epilepsy, ophthalmia and dermatological disorders in endemic developing countries. Tanzania is among the sub-Saharan African countries with an average prevalence of porcine cysticercosis 17.2% [1], which increases the risk of human cysticercosis infection. Studies on people with epilepsy in northern zone of Tanzania show a 16.2% [2] to be suffering from neurocysticercosis. While this was the case, there were no single report on the prevalence of human cysticercosis neither to regular hospital visitors, admissions, and nor general public that result to insufficient deployment of intervention strategies. Study was performed to assess the prevalence of human cysticercosis in general public in Mbulu district. The cephalic venous blood was collected from assorted community members. Serum was extracted and then subjected to Cysticercus IgG Western Blot Assay for human cysticercosis sero-screening. It was found that about 16.3% of the community members had antibodies signifying infection by human cysticercosis. This is the first ever study to assess the prevalence of human cysticercosis in the country and it has revealed the problem to be very high. This study can be valuable for deployment of appropriate intervention measures on human cysticercosis in the study area and extend to the entire country.

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B. J. Mwang’onde, G. Nkwengulila and M. Chacha, "The Serological Survey for Human Cysticercosis Prevalence in Mbulu District, Tanzania," Advances in Infectious Diseases, Vol. 2 No. 3, 2012, pp. 62-66. doi: 10.4236/aid.2012.23009.

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The authors declare no conflicts of interest.


[1] I. K. Phiri, H. Ngowi, S. Afonso, E. Matenga, M. Boa, S. Mukaratirwa, S. Githigia, M. Saimo, C. Sikasunge, N. Maingi, et al., “The Emergence of Taenia Solium Cysticercosis in Eastern and Southern Africa as a Serious Agricultural Problem and Public Health Risk,” Acta Tropica, Vol. 87, No. 1, 2003, pp. 13-23.
[2] A. S. Winkler, J. Blocher, H. Auerd, T. Gotwalde, W. Matuja and E. Schmutzhard, “Anticysticercal and Antitoxocaral Antibodies in People with Epilepsy in Rural Tanzania,” Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 102, No. 10, 2008, pp. 1032-1038.
[3] N. Praet, K. Kanobana, C. Kabwe, V. Maketa, P. Lukanu, P. Lutumba, K. Polman, P. Matondo, N. Speybroeck et al, “Taenia Solium Cysticercosis in the Democratic Republic of Congo: How Does Pork Trade Affect the Transmission of the Parasite?” PLOS Neglected Tropical Diseases, Vol. 4, No. 9, 2010, p. e817. doi:10.1371/journal.pntd.0000817
[4] R. W. Tolan, “Taenia Infection,” 2011. http://wwwtheinfectiousdiseasesdailyom/
[5] F. Fregni, “Taenia Solium (Taeniasis/Cysticercosis),” Collaborative Course on Infectious Diseases, 2008.
[6] H. A. Ngowi, I. K. Phiri, S. Afonso, E. Matenga, M. E. Boa, S. Mukaratirwa, S. Githigia, M. Saimo, C. Sikasunge, N. Maingi, et al., “Taenia Solium Cysticercosis in Eastern and Southern Africa: An Emerging Problem in Agriculture and Public Health,” Southeast Asian Journal of Tropical Medicine and Public Health, Vol. 35, No. 1, 2004, pp. 266-270.
[7] F. Sorvillo, P. Wilkins, S. Shafir and M. Eberhard, “Public Health Implications of Cysticercosis Acquired in the United States,” Emerging Infectious Diseases, Vol. 17, No. 1, 2011, pp. 1-6.
[8] K. Swastika, C. I. Dewiyani, T. Yanagida, Y. Sako, M. Sudarmaja, P. Sutisna, T. Wandra, N. S. Dharmawan, K. Nakaya, M. Okamoto, et al., “An Ocular Cysticercosis in Bali, Indonesia Caused by Taenia Solium Asian Genotype,” Parasitology International, Vol. 61, No. 2, 2012, pp. 378-380. doi:10.1016/j.parint.2011.11.004
[9] I. Francis, P. R. Hira, N. A. Abdella, R. Gupta, F. M. Al-Ali, S. Grover, N. Khalid, S. Abdeen, J. Iqbal, M. Wilson and V. C. Tsang, “Cysticercosis: Imported and Autochthonous Infections in Kuwait,” Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 98, No. 4, 2004, pp. 233-239. doi:10.1016/S0035-9203(03)00061-0
[10] W. C. Cao, P. C. Van Der, C. L. Gao, J. F. Xu, X. C. Cao, Z. H. Cui, Z. X. Ren and J. D. F. Habbema, “Seroprevalence and Risk Factors of Human Cysticercosis in a Community of Shandong, China,” Southeast Asian Journal of Tropical Medicine and Public Health, Vol. 27, No. 2, 1996, pp. 279-285.
[11] C. P. Raccurt, P. Agnamey, J. Boncy, J.-H. Henrys and A. Totet, “Seroprevalence of Human Taenia Solium Cysticercosis in Haiti,” Journal of Helminthology, Vol. 83, No. 2, 2009, pp. 113-116.
[12] N. A. Mafojanea, C. C. Appletonb, R. C. Krecekc, L. M. Michaeld and A. L. Willingham III, “The Current Status of Neurocysticercosis in Eastern and Southern Africa,” Acta Tropica, Vol. 87, No. 1, 2003, pp. 25-33.
[13] A. L. Willingham III and A. Mugarura, “Taenia Solium Tapeworms and Epilepsy in Uganda,” International Epilepsy News, Vol. 1, 2008, pp. 10-12.
[14] D. K. Pal, A. Carpio and J. W. A. S. Sander, “Neurocysticercosis and Epilepsy in Developing Countries,” Journal of Neurology, Neurosurgery and Psychiatry, Vol. 68, No. 2, 2000, pp. 137-143.
[15] European Commission, “Opinion of the Scientific Committee on Veterinary Measures Relating to Public Health on the Control of Taeniosis/Cysticercosis in Man and Animals,” Health & Consumer Protection Directorate General, Brussels, 2000.
[16] N. M. Canas, S. L. Calado and J. Vale, “Treatment of Racemose Neurocysticercosis of the Spine,” Revista de Neurologia, Vol. 40, No. 9, 2005, pp. 544-547.
[17] P. M. Schantz, P. P. Wilkins and V. C. W. Tsang, “Immigrants, Imaging, and Immunoblots: The Emergence of Neurocysticercosis as a Significant Public Health Problem,” In: W. M. Scheld, W. A. Craig and J. M. Hughes, Eds., Emerging Infections 2, ASM Press, Washington DC, 1998, pp. 213-242.
[18] W. X. Shandera and J. S. Kass, “Neurocysticercosis: Current Knowledge and Advances,” Current Neurology and Neuroscience Reports, Vol. 6, No. 6, 2006, pp. 453-459. doi:10.1007/s11910-006-0046-3
[19] M. V. Johansen, “Draft Action Plan for Prevention and Control of Taenia Solium Cysticercosis/Taeniosis in Eastern and Southern African Region,” Cysticercosis Working Group in Eastern and Southern Africa, Morogoro, 2008.
[20] A. Secka, T. Marcotty, R. De Deken, E. V. Marck and S. Geerts, “Porcine: Cysticercosis and Risk Factors in the Gambia and Senegal,” Journal of Parasitology Research, Vol. 2010, 2010, Article ID: 823892.
[21] M. E. Boa, E. A. Mahundi, A. A. Kassuku, A. L. Willingham III and N. C. Kyvsgaard, “Epidemiological Survey of Swine Cysticercosis Using Ante-Mortem and Post-Mortem Examination Tests in the Southern Highlands of Tanzania,” Veterinary Parasitology, Vol. 139, No. 1-3, 2006, pp. 249-255. doi:10.1016/j.vetpar.2006.02.012
[22] H. A. Ngowi, A. A. Kassuku, G. E. Maeda, M. E. Boa, H. Carabin and A. L. Willingham, “Risk Factors for the Prevalence of Porcine Cysticercosis in Mbulu District, Tanzania,” Veterinary Parasitology, Vol. 120, No. 4, 2004, pp. 275-283.
[23] F. P. Lekule and N. C. Kyvsgaard, “Improving Pig Husbandry in Tropical Resource-Poor Communities and Its Potential to Reduce Risk of Porcine Cysticercosis,” Acta Tropica, Vol. 87, No. 1, 2003, pp. 111-117. doi:10.1016/S0001-706X(03)00026-3
[24] E. M. Mkupasi, H. A. Ngowi and H. E. Nonga, “Prevalence of Extra-Intestinal Porcine Helminth Infections and Assessment of Sanitary Conditions of Pig Slaughter Slabs in Dares Salaam City, Tanzania,” Tropical Animal Health and Production, Vol. 43, No. 2, 2010, pp. 417-423. doi:10.1007/s11250-010-9708-x
[25] A. L. Willingham, L. J. Harrison, E. M. Fèvre and M. E. Parkhouse, “Inaugural Meeting of the Cysticercosis Working Group in Europe,” Emerging Infectious Diseases, Vol. 14, No. 12, 2008. doi:10.3201/eid1412.080889
[26] C. Simac, P. Michel, A .Andriantsimahavandy, P. Esterre and A. Michault, “Use of Enzyme-Linked Immunosorbent Assay and Enzyme-Linked Immunoelectrotransfer Blot for the Diagnosis and Monitoring of Neurocysticercosis,” Parasitology Research, Vol. 81, No. 2, 1995, pp. 132-136. doi:10.1007/BF00931618
[27] G. Mwanjali, “Prevalence and Practices Associated with Human Taenia Solium Infection in Mbozi District, Mbeya Region,” Dissertation, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, 2010.
[28] E. Newell, F. Vyungimana, S. Geerts, I. Van Kerckhoven, V. C. W. Tsang and D. Engels, “Prevalence of Cysticercosis in Epileptics and Members of Their Families in Burundi,” Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 91, No. 4, 1997, pp. 389-391. doi:10.1016/S0035-9203(97)90251-0
[29] A. Zoli, O. Shey-Njila, E. Assana, J.-P. Nguekam, P. Dorny, J. Brandt and S. Geerts, “Regional Status, Epidemiology and Impact of Taenia Solium Cysticercosis in Western and Central Africa,” Acta Tropica, Vol. 87, No. 1, 2003, pp. 35-42. doi:10.1016/S0001-706X(03)00053-6
[30] G. Nsengiyumva, M. Druet-Cabanac, B. Ramanankandrasana, B. Bouteille, L. Nsizabira and P. M. Preux, “Cysticercosis as a Major Risk Factor for Epilepsy in Burundi, East Africa,” Epilepsia, Vol. 44, No. 7, 2003, pp. 950-955.
[31] S. H. Vora, D. D. Motghare, A. M. Ferreira, M. S. Kulkan and S. F. Vaz, “High Prevalence of Human Cysticercosis in a Rural Village in Western India,” Tropical Medicine and Health, Vol. 36, No. 3, 2008, pp. 137-138.
[32] URT, “Tanzania country profile,” 2012.

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