Management of vitamin D deficiency in young women with 1-year follow up


Vitamin D deficiency is very frequently observed among young women. This study reports the follow up of 68 women over a period of 1 year. The objective of this study was to observe doses of vitamin D can correct and preserve blood levels of vitamin D near 75 nmol/L. It was found that large amounts of vitamin D are needed to correct and then maintain vitamin D blood levels (≥530,000 units), particularly in veiled women (~720,000 units). Parathyroid hormone (PTH) levels decreased as blood levels of vitamin D increased. Quality of life measured with the SF12? Health Survey questionnaire, improved when the patients’ vitamin D deficiencies were corrected. This work highlights the need for the development of guidelines to treat and correct vitamin D deficiency for the long term in young adult women.

Share and Cite:

Perdrix, C. , Large, O. , Fauché, R. , Dupraz, C. and LeGoaziou, M. (2012) Management of vitamin D deficiency in young women with 1-year follow up. Open Journal of Preventive Medicine, 2, 312-317. doi: 10.4236/ojpm.2012.23045.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Le Goaziou, M.F., Contardo, G., Dupraz, C., Martin, A., Laville, M. and Schott-Pethelaz, A.M. (2011) Risk factors for vitamin D deficiency in women aged 20-50 years consulting in general practice: A cross-sectional study. European Journal of General Practice, 17, 146-152.
[2] De Torrente de la Jara, G., Pecoud, A. and Favrat, B. (2006) Female asylum seekers with muscu-loskeletal pain: The importance of diagnosis and treatment of hypovita- minosis D. BMC Family Practice, 7, 4. doi:10.1186/1471-2296-7-4
[3] Turner, M.K., Hooten, W.M., Schmidt, J.E., Kerkvliet, J.L., Townsend, C.O. and Bruce, B.K. (2008) Prevalence and clinical correlates of vitamin D inadequacy among patients with chronic pain. Pain Medicine, 9, 979-984. doi:10.1111/j.1526-4637.2008.00415.x
[4] Vieth, R., Kimball, S., Hu, A. and Walfish, P.G. (2004) Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutrition Journal, 3, 8. doi:10.1186/1475-2891-3-8
[5] Gandek, B., Ware, J.E., Aaronson, N.K., Alonso, J., Apolone, G., Bjorner, J., Brazier, J., Bullinger, M., Fukuhara, S., Kaasa, S., Leplège, A. and Sullivan, A. (1998) Tests of data quality, scaling assumptions, and reliability of the SF-36 in eleven countries: Results from the IQOLA Project. International Quality of Life Assessment. Journal of Clinical Epidemiology, 51, 1149-1158. doi:10.1016/S0895-4356(98)00106-1
[6] Holick, M.F. (2007) Vitamin D deficiency. New England Journal of Medicine, 357, 266-281.
[7] Vieth, R., Chan, P.C. and MacFarlane, G.D. (2001) Efficacy and safety of vitamin D3 intake exceeding the low- est observed adverse effect level. American Journal of Clinical Nutrition, 73, 288-294.
[8] Levis, S., Gomez, A., Jimenez, C., Veras, L., Ma, F., Lai, S., Hollis, B. and Roos, B.A. (2005) Vi-tamin D deficiency and seasonal variation in an adult South Florida population. Journal of Clinical Endocrinology & Metabolism, 90, 1557-1562. doi:10.1210/jc.2004-0746
[9] Saadi, H.F., Dawodu, A., Afandi, B.O., Zayed, R., Benedict, S. and Nagelkerke, N. (2007) Efficacy of daily and monthly high-dose calciferol in vitamin D-deficient nulliparous and lactating women. American Journal of Clinical Nutrition, 85, 1565-1571.
[10] Aloia, J.F., Patel, M., Dimaano, R., Li-Ng, M., Talwar, S.A., Mikhail, M., Pollack, S. and Yeh, J.K. (2008) Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration. American Journal of Clinical Nutrition, 87, 1952-1958.
[11] Vieth, R. (1999) Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. American Journal of Clinical Nutrition, 69, 842-856.
[12] Heaney, R.P. (2008) Vitamin D: Criteria for safety and efficacy. Nutrition Reviews, 66, S178-S181. doi:10.1111/j.1753-4887.2008.00102.x
[13] Hathcock, J.N., Shao, A., Vieth, R. and Heaney, R. (2007) Risk as-sessment for vitamin D. American Journal of Clinical Nutrition, 85, 6-18.
[14] Aloia, J.F., Talwar, S.A., Pollack, S., Feuerman, M. and Yeh, J.K. (2006) Optimal vitamin D status and serum parathyroid hormone concentrations in African American women. American Journal of Clinical Nutrition, 84, 602- 609.
[15] Heaney, R.P., Davies, K.M., Chen, T.C., Holick, M.F. and Barger-Lux, M.J. (2003) Human serum 25-hydroxy-cholecalciferol response to extended oral dosing with cholecalciferol. American Journal of Clinical Nutrition, 77, 204-210.
[16] Lips, P., Duong, T., Oleksik, A., Black, D., Cummings, S., Cox, D. and Nickelsen, T. (2001) A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: Baseline data from the multiple outcomes of raloxifene evaluation clinical trial. Jour- nal of Clinical Endocrinology & Metabolism, 86, 1212-1221. doi:10.1210/jc.86.3.1212
[17] Holick, M.F., Binkley, N.C., Bischoff-Ferrari, H.A., Gordon, C.M., Hanley, D.A., Heaney, R.P., Murad, M.H. and Weaver, C.M. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline. Journal of Clinical Endocrinology & Meta-bolism, 96, 1911-1930.

Copyright © 2022 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.