Share This Article:

Synthesis, characterization and biocidal properties of platinum metal complexes derived from 2,6-diacetylpyridine (bis thiosemicarbazone)

Abstract Full-Text HTML Download Download as PDF (Size:577KB) PP. 41-48
DOI: 10.4236/ojic.2012.23007    7,435 Downloads   15,213 Views   Citations

ABSTRACT

The coordination compounds of PdII, PtII, RhIII and IrIII metal ions with a Schiff base ligand (L) i.e. 2,6- diacetylpyridine bis(thiosemicarbazone) have been synthesized and characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, IR, NMR and electronic spectral studies. On the basis of molar conductance and elemental analyses the complexes were found to have composition [M(L)]Cl2 and [M’(L)Cl]Cl2, where M = Pd(II), Pt(II) and M’ = Rh(III), Ir(III). The spectral studies reveal that the complexes possess monomeric composition. Complexes of PdII and PtII were found to have four coordinated square planar geometry whereas the complexes of RhIII and IrIII posses six coordinated octahedral geometry. The ligand field parameters were calculated using various energy level diagrams. In vitro synthesized compounds and metal salts have been tested against some species of plant pathogenic fungi and bacteria in order to assess their antimicrobial properties.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Tyagi, M. and Chandra, S. (2012) Synthesis, characterization and biocidal properties of platinum metal complexes derived from 2,6-diacetylpyridine (bis thiosemicarbazone). Open Journal of Inorganic Chemistry, 2, 41-48. doi: 10.4236/ojic.2012.23007.

References

[1] Mishra, D., Naskar, S., Drew, M.G.B. and Chattopadhyay, S.K. (2006) Synthesis, spectroscopic and redox properties of some ruthenium(II) thiosemicarbazone complexes: Structural description of four of these complexes. Inorganica Chimica Acta, 359, 585-592. doi:10.1016/j.ica.2005.11.001
[2] Agarwal, R.K. and Prasad, S. (2005) Synthesis and spectral investigations of some platinum metals ions coordination compounds of 4[N-(furan-2′-carboxalidene)amino] antipyrine thiosemicarbazone and 4[N-(3′,4′,5′-trime-thoxybenzalidene) amino]antipyrine thiosemicarbazone. Turkish Journal of Chemistry, 29, 289-297.
[3] Patil, S.A., Naik, V.H., Kulkarni A.D. and Badami P.S. (2010) DNA cleavage, antimicrobial, spectroscopic and fluorescence studies of Co(II), Ni(II) and Cu(II) complexes with SNO donor coumarin Schiff bases. Spectrochimica Acta A, 75, 347-354. doi:10.1016/j.saa.2009.10.039
[4] Sharma, K., Singh, R., Fahmi, N. and Singh, R.V. (2010) Microwave assisted synthesis, characterization and biological evaluation of palladium and platinum complexes with azomethines. Spectrochimica Acta A, 75, 422-427. doi:10.1016/j.saa.2009.10.052
[5] Al-Amiery, A.A., Al-Majedy, Y.K., Abdulreazak, H. and Abood, H. (2011) Synthesis, characterization, theoretical crystal structure, and antibacterial activities of some transition metal complexes of the thiosemicarbazone (Z)-2(pyrrolidin-2-ylidene)hydrazinecarbothioamide. Bioinorganic Chemistry and Applications, 2011, 1-6. Article ID 483101.
[6] Wiecek, J., Kovala-Demertzi, D., Ciunik, Z., Zervou, M. and Demertzis, M.A. (2010) Diorganotin complexes of a thiosemicarbazone, synthesis: Properties, x-ray crystal structure, and antiproliferative activity of diorganotin complexes. Bioinorganic Chemistry and Applications, 2010, 1-9. Article ID 867195.
[7] Ferraz, K.O., Wardell, S.M.S.V., Wardell, J.L., Louro, S.R.W. and Beraldo, H. (2009) Copper(II) complexes with 2-pyridineformamide-derived thiosemicarbazones: Spectral studies and toxicity against Artemia salina. Spectrochimica Acta A, 73, 140-145. doi:10.1016/j.saa.2009.02.020
[8] Graminha, A.E., Batista, A.A., Mendes, I.C., Teixeira, L.R. and Beraldo, H. (2008) Ruthenium(II) complexes containing 2-pyridineformamideand 2-benzoylpyridinederived thiosemicarbazones and PPh3: NMR and electrochemical studies of cis-trans-isomerization. Spectrochimica Acta A, 69, 1277-1282. doi:10.1016/j.saa.2007.07.005
[9] Raja, N. and Ramesh, R. (2010) Mononuclear ruthenium(III) complexes containing chelating thiosemicarbazones: Synthesis, characterization and catalytic property. Spectrochimica Acta A, 75, 713-718. doi:10.1016/j.saa.2009.11.044
[10] Bakir, J.A. and Dissouky, E.I. (2005) Synthesis, spectroscopic and the biological activity studies of thiosemicarbazones containing ferrocene and their copper(II) complexes. Journal of Coordination Chemistry, 58, 10291038. doi:10.1080/00958970500096975
[11] Chandra, S., Tyagi, M. and Agrawal, S. (2010) Spectral and antimicrobial studies on tetraaza macrocyclic complexes of PdII, PtII, RhIII and IrIII metal ions. Journal of Saudi Chemical Society, 15, 49-54. doi:10.1016/j.jscs.2010.09.005
[12] Chandra, S. and Kumar, A. (2007) Spectral studies on Co(II), Ni(II) and Cu(II) complexes with thiosemicarbazone(L1) and semicarbazone(L2) derived from 2-acetyl furan. Spectrochimica Acta A, 66, 1347-1351. doi:10.1016/j.saa.2006.04.047
[13] Kumar, U. and Chandra, S. (2010) Biological active cobalt(II) and nickel(II) complexes of 12-membered hexaaza [N6] macrocyclic ligand: Synthetic and spectroscopic aspects. E-Journal of Chemistry, 7, 1238-1245. doi:10.1155/2010/518723
[14] Chandra, S., Verma, S., Dev, U. and Joshi, N. (2009) Tetraaza macrocyclic complexes: Synthesis, spectral and antimicrobial studies. Journal of Coordination Chemistry, 62, 1327-1335. doi:10.1080/00958970802521076
[15] Refat, M.S., Chandra, S. and Tyagi, M. (2010) Spectroscopic, thermal and biocidal studies on Mn(II), Co(II), Ni(II) and Cu(II) complexes of tridentate ligand having semicarbazone moieties. Journal of Thermal Analysis and Calorimetry, 61, 261-267. doi:10.1007/s10973-009-0397-5
[16] Agarwal, R.K., Singh, L. and Sharma, (2006) Synthesis, spectral and biological properties of copper(II) complexes of thiosemicarbazones of schiff bases derived from 4aminoantipyrine and aromatic aldehyde. Bioinorganic Chemistry and Applications, 2006, 1-10. Article ID 59509.
[17] Chandra, S., Raizada, S., Tyagi, M. and Sharma, P. (2008) Spectroscopic and biological approach of Ni(II) and Cu(II) complexes of 2-pyridinecarboxald-ehyde thiosemicarbazone. Spectrochimica Acta A, 69, 816-821. doi:10.1016/j.saa.2007.05.033
[18] Sharma, K., Singh, R. and Fahmi, N. (2010) Microwave assisted synthesis, characterization and biological evaluation of palladium and s with azomethines. Spectrochimica Acta A, 75, 422-427. doi:10.1016/j.saa.2009.10.052
[19] Wehrli, F.W., Marchand, A.P. and Wehrli, S. (1988) Interpretation of Carbon-13NMR Spectra. 2nd Edition, Wiley, New York.
[20] Deepa, K.P. and Aravindakshan, K.K. (2000) Synthesis, characterizationand thermal studies of thiosemicarbazones of N-methylandN-ethylacetoacetanilide. Synthesis and Reactivity in Inorganic, Metal-Organic, and NanoMetal Chemistry, 30, 1601-1616.
[21] Joseph, M., Sreekanth, A., Suni, V. and Kurup, M.R.P. (2006) Spectral characterization of iron(III) complexes of 2-benzoylpyridineN(4)-substituted thiosemicarbazones. Spectrochimica Acta A, 64, 637-641. doi:10.1016/j.saa.2005.07.067
[22] Singh, R.V., Biyala, M.K. and Fahmi, N. (2005) Important properties of sulfur-bonded organoboron(III) complexes with biologically potent ligands. Phosphorus, Sulfur and Silicon and the Related Elements, 180, 425-434. doi:10.1080/104265090509225
[23] Chandra, S. and Gupta, L.K. (2005) EPR, masss, IR, electronic and magnetic studies on copper(II) complexes of semicarbazones and thiosemicarbazones. Spectrochimica Acta A, 61, 269-275.
[24] Bailey, R.A., Kozak, S.L., Michelson, T.W. and Mills, W.N. (1971) Infrared spectra of complexes of the thio ions. Coordination Chemistry Reviews, 6, 407-445.
[25] Singh, S., Bharti, N., Naqvi, F. and Azam, A. (2004) Synthesis, characterization and in vitro antiamoebic activity of 5 nitrothiophene-2-carboxaldehyde thiosemicarbazones and their Palladium(II) and Ruthenium(II) complexes. European Journal of Medicinal Chemistry, 39, 459-465.
[26] Chandra, S., Raizada, S. and Rani, S. (2008) Structural and spectral studies of palladium(II) and platinum(II) complexes derived from N,N,N,N-tetradentate macrocyclic ligands. Spectrochimica Acta A, 71, 720-724.
[27] Jorgensen, C.K. (1964) Absorption Spectra and Chemical Bonding in Complexes. Pergamon Press, London.
[28] Chandra, S. and Singh, R. (1988) Pd(II), Pt(II), Rh(III), Ir(III) and Ru(III) complexes of some nitrogen-oxygen donor ligands. Indian Journal of Chemistry, 27, 417420.
[29] Chandra, S., Kumar, S. and Rani, S. (2011) Synthesis, structural, spectral, thermal and antimicrobial studies of palladium(II), platinum(II), ruthenium(III) and iridium(III) complexes derived from N,N,N,N-tetradentate macrocyclic ligand. Spectrochimica Acta A, 78, 1507-1514.
[30] El-Behery, M. and El-Twigry, H. (2007) Synthesis, magnetic, spectral, and antimicrobial studies of Cu(II), Ni(II) Co(II), Fe(III), and UO2(II) complexes of a new Schiff base hydrazone derived from 7-chloro-4-hydrazinoquinoline. Spectrochimica Acta A, 66, 28-36.
[31] Tyagi, M. and Chandra, S. (2012) Chromium(III) and manganese(II) complexes of macrocyclic ligand containing thiosemicarbazide moiety: Spectroscopic and biological studies. Journal of the Indian Chemical Society, 89, 147-154.
[32] Chandra, S. and Tyagi, M. (2008) Ni(II), Pd(II) and Pt(II) complexes with ligand containing thiosemicarbazone and semicarbazone moiety: Synthesis, characterization and biological investigation. Journal of the Serbian Chemical Society, 73, 727-734.

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.