Antitumor Activity of Disintegrin-Like Components from the Venom of Montivipera raddei

DOI: 10.4236/jct.2011.25101   PDF   HTML     4,343 Downloads   7,098 Views   Citations


Our findings represent the first report of the antitumor activity of the disintegrin-like components from the venom of Armenian viper (M. raddei). The venom of M. raddei was separated by reverse phase high-performance liquid chroma-tography (RP HPLC), and individual fractions were analyzed for disintegrin activity. Disintegrin-like components from the venom of M. raddei, by blocking integrins on breast cancer cells (MDA-MB-435), not only interferes with adhesion of breast cancer cells to the extracellular matrix, but also inhibits cellular mobility which is essential for cancer invasion. These effects seriously curtail the metastatic capability of the MDA-MB-435 cells.

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S. Amiryan, "Antitumor Activity of Disintegrin-Like Components from the Venom of Montivipera raddei," Journal of Cancer Therapy, Vol. 2 No. 5, 2011, pp. 752-759. doi: 10.4236/jct.2011.25101.

Conflicts of Interest

The authors declare no conflicts of interest.


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