Estimation of the galanthamine using derivative spectrophotometry in bulk drug and formulation

Karan Mittal; Ramni Kaushal; Rajashree Mashru; Arti Thakkar

doi:10.4236/jbise.2010.34060

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JBiSE> Vol.3 No.4, April 2010

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Estimation of the galanthamine using derivative spectrophotometry in bulk drug and formulation

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DOI: 10.4236/jbise.2010.34060 8,388 Downloads 13,253 Views Citations

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Karan Mittal, Ramni Kaushal, Rajashree Mashru, Arti Thakkar

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ABSTRACT

Two simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for the determination of galanthamine hydrobromide (GH) in bulk and pharmaceutical formulation. First method is zero order UV spectrophotometry and second is 1st derivative zero crossing spectrophotometry. The developed methods have shown best results in terms of linearity, accuracy, precision, LOD and LOQ for bulk drugs and marketed formulations. Absorbance was measured at 287 nm for zero order and 277.4 nm for first derivative. It obeyed Lambert-Beer’s law in the range of 30-80 μg mL-1. Both methods have good linearity (r2 = 0.9997) and accuracy found to be 100.5% and 101.2% for both methods respectively.

KEYWORDS

alanthamine Hydrobromide (GH); Zero Order UV-Spectrophotometry; First Derivative Zero Crossing Spectrophotometry

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Mittal, K. , Kaushal, R. , Mashru, R. and Thakkar, A. (2010) Estimation of the galanthamine using derivative spectrophotometry in bulk drug and formulation. Journal of Biomedical Science and Engineering, 3, 439-441. doi: 10.4236/jbise.2010.34060.

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