Estimation of the galanthamine using derivative spectrophotometry in bulk drug and formulation

Karan Mittal; Ramni Kaushal; Rajashree Mashru; Arti Thakkar

doi:10.4236/jbise.2010.34060

Home > Journals > Biomedical & Life Sciences > JBiSE

Journal of Biomedical Science and Engine... > Vol.3 No.4, April 2010

Estimation of the galanthamine using derivative spectrophotometry in bulk drug and formulation ()

Karan Mittal, Ramni Kaushal, Rajashree Mashru, Arti Thakkar

DOI: 10.4236/jbise.2010.34060 PDF HTML 8,533 Downloads 13,455 Views Citations

Abstract

Two simple, rapid, accurate, precise, reliable and economical spectrophotometric methods have been proposed for the determination of galanthamine hydrobromide (GH) in bulk and pharmaceutical formulation. First method is zero order UV spectrophotometry and second is 1st derivative zero crossing spectrophotometry. The developed methods have shown best results in terms of linearity, accuracy, precision, LOD and LOQ for bulk drugs and marketed formulations. Absorbance was measured at 287 nm for zero order and 277.4 nm for first derivative. It obeyed Lambert-Beer’s law in the range of 30-80 μg mL-1. Both methods have good linearity (r2 = 0.9997) and accuracy found to be 100.5% and 101.2% for both methods respectively.

Keywords

alanthamine Hydrobromide (GH); Zero Order UV-Spectrophotometry; First Derivative Zero Crossing Spectrophotometry

Share and Cite:

Mittal, K. , Kaushal, R. , Mashru, R. and Thakkar, A. (2010) Estimation of the galanthamine using derivative spectrophotometry in bulk drug and formulation. Journal of Biomedical Science and Engineering, 3, 439-441. doi: 10.4236/jbise.2010.34060.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Ping, J., Rong, S., Jing, Z., Liang, F., Qiaojun, H. and Yongzhou, H. (2008) Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry, 44 (12), 772-784.
[2]	Traykova, M., Traykov, T., Hadjimitova, V., Krikorian, K. and Bojadgieva, N. (2003) Antioxidant Properties of Galantamine Hydrobromide. Zeitschrift für Naturforschung, 58c, 361-365.
[3]	Heinrich, M. and Teoh, H.L. (2004) Galanthamine from snowdrop-the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. Journal of Ethno pharmacology, 92, 147-162.
[4]	Scott, L.J. and Goa, K.L. (2000) Galantha mine: A review of its use in Alzheimer's disease. Adis Review, 60(5), 1095-122.
[5]	Novikova, I.Y. and Tulaganov, A.A. (2002) Physicochemical methods for the analysis of galanthamine (review). Pharmaceutical Chemistry Journal, 36(11), 623-627.