Author(s)

Ichiro Kurokawa^1*, Masako Watanabe², Kazuhito Hayashibe³

¹Department of Dermatology, Meiwa Hospital, Nishinomiya, Hyogo, Japan.
²Kobayashi Skin Clinic, Kobe, Japan.
³Hayashibe Skin Clinic, Sanda, Japan.

Postinflammatory hyperpigmentation (PIH) and postinflammatory erythema (PIE) in acne vulgaris are important and refractory complications for patients with acne vulgaris. To clarify the effects of 2% isostearyl-L-ascorbic acid (ISAA) against PIH and PIE in acne vulgaris, a clinical pilot study with topical 2% ISAA gel was performed in 25 acne patients with PIH and PIE. Topical ISAA gel was applied on the whole face with PIH and PIE in acne vulgaris twice a day for 3 months. Regarding PIH and PIE, investigator’s global improvement rating (IGIR) was evaluated in 7-point scales according to the reduced area of PIH and PIE before and after the study. Remarkable improvement in PIH was observed in 7 patients (28.0%) and in PIE in 12 (48%) of the 25 patients. No adverse reactions were observed during the treatment. Topical ISAA application can be an alternative, non-invasive available treatment for PIH and PIE in acne vulgaris.

Acne, Vitamin C, Postinflammatory Hyperpigmentation, Postinflammatory Erythema

Kurokawa, I. , Watanabe, M. and Hayashibe, K. (2020) Effect of a Cosmetic Use with 2% Isostearyl-L-Ascorbic Acid Gel for Postinflammatory Hyperpigmentation and Postinflammatory Erythema in Acne Vulgaris. Journal of Cosmetics, Dermatological Sciences and Applications, 10, 28-32. doi: 10.4236/jcdsa.2020.101004.