31P MR Spectroscopy with 3D Chemical-Shift Imaging Detects Changes in Levels of Phosphorus Metabolites Due to Saliva Secretion in Human Parotid Glands ()
ABSTRACT
.Objectives: To measure phosphorus metabolites in human parotid glands by 31P-MRS
using three-dimensional chemical-shift imaging (3D-CSI), and ascertain whether
this method can capture changes in adenosine triphosphate (ATP) and
phosphocreatine (PCr) levels due to saliva secretion. Study Design: The
parotid glands of 20 volunteers were assessed by 31P-MRS using
3D-CSI on 3T MRI. After obtaining a first (baseline) measurement, the
participants took vitamin-C tablets and measurements were obtained twice more,
in a continuous manner. The peak area ratios of PCr
and β-ATP were evaluated. Results: A high proportion of PCr (0.26 ± 0.08)
and ATP (α: 0.16 ± 0.06; β: 0.27 ± 0.06; γ: 0.21 ± 0.03) was noted at baseline. A significant decrease in β-ATP was observed between baseline
(“pre”; 0.27 ± 0.06) and the first scan after vitamin-C stimulation (“post-1”;
0.19 ± 0.07, p < 0.05). There was a near-significant decrease in PCr between pre (0.26 ± 0.08) and post-1 (0.23
± 0.06, p = 0.074). Conclusions: 31P-MRS with 3D-CSI can
assess the major phosphorus metabolites in human parotid glands and capture
changes in their levels due to saliva secretion. This technique is simple,
non-invasive, and provides new information regarding saliva secretion.
Share and Cite:
Sato, T. , Isoda, H. and Togashi, K. (2020)
31P MR Spectroscopy with 3D Chemical-Shift Imaging Detects Changes in Levels of Phosphorus Metabolites Due to Saliva Secretion in Human Parotid Glands.
Open Journal of Medical Imaging,
10, 42-51. doi:
10.4236/ojmi.2020.101004.