Author(s)

Magara Samaké^1,2*, Seydou Sy^2,3, Hamadoun Yattara^2,3, Moctar Coulibaly⁴, Mamadou Badou Sanogo², Aboubacar Sidiki Fofana², Aboudou Messoum Dolo⁵, Djénéba Maiga⁵, Djénéba Diallo^2,3, Atabieme Kodio², Bakary Diarra¹, Karamoko Djiguiba⁶, Djibril Sy⁷, Saharé Fongoro^2,3

¹Nephrology Unit of the Fousseyni DAOU Hospital, Kayes, Mali.
²Nephrology and Haemodialysis Department of the CHU of Point G, Bamako, Mali.
³Faculty of Medicine of Bamako, University of Bamako, Bamako, Mali.
⁴Nephrology Unit of Mali GAVARDO Hospital, Bamako, Mali.
⁵Nephrology Unit of the Sikasso Regional Hospital, Sikasso, Mali.
⁶Nephrology Unit of the Mother and Child Hospital, The Luxembourg, Bamako, Mali.
⁷Internal Medicine Service of the University Hospital Center of Point G, Bamako, Mali.

Introduction: Chronic kidney disease (CKD) is the progressive and irreversible loss of kidney function. It exposes to many complications, among which, digestive complications. In Mali, we do not have data on the prevalence of digestive pathologies in people with chronic renal failure, hence the interest of this study. Objective: To determine the prevalence of digestive pathologies and to describe their manifestations during chronic renal failure. Patients and Methods: This was a prospective cross-sectional study conducted from September 2016 to August 2017, a period of 12 months. Included were patients hospitalized in our department with CKD who received digestive endoscopy and/or liver serology. Results: Seventy-one patients underwent digestive endoscopy with oesogastroduodenal fibroscopy (60 patients), rectoscopy (6 patients) and anoscopy (5 patients), i.e. 15.9% of those hospitalized. The mean age of the patients was 48 ± 14 years with extremes of 15 and 84 years. The sample consisted of 59.2% men versus 40.8% women, for a sex ratio of 1.5. The functional signs are in order of frequency: vomiting (72.4%), anorexia (51.3%) and epigastralgia (48.7%). Terminal CKD by creatinine clearance accounted for 88.2% of cases, of which 47.4% were monitored by hemodialysis. Hepatitis C virus infection was present in 21.3% of cases, hepatitis B (18%) and HIV (7.5%). Endoscopic examinations were represented by fibroscopy (84.5%), rectoscopy (8.5%) and anuscopy (7%). The fibroscopic lesions were respectively gastric (96.8%), duodenal (14.1%) and esophageal (12.5%). They were dominated by gastritis (40.5%), duodeno-gastric reflux (16.4%), pyloric gap (12.6%). Rectoscopy found 4 cases of hemorrhoids, 2 cases of rectitis and no lesions were observed at anuscopy. Conclusion: The prevalence of these digestive manifestations and the endoscopic lesions encountered indicate the importance of digestive endoscopy and the performance of hepatic serologies in chronic renal failure patients with digestive symptoms and/or treated by hemodialysis.

Chronic Renal Failure, Digestive Signs, Mali

Samaké, M. , Sy, S. , Yattara, H. , Coulibaly, M. , Sanogo, M. , Fofana, A. , Dolo, A. , Maiga, D. , Diallo, D. , Kodio, A. , Diarra, B. , Djiguiba, K. , Sy, D. and Fongoro, S. (2020) Digestive Pathologies during Chronic Renal Failure in the Nephrology and Haemodialysis Department at the University Hospital Center of Point G in Mali. Open Journal of Clinical Diagnostics, 10, 41-48. doi: 10.4236/ojcd.2020.101004.