International Journal of Organic Chemistry

Volume 9, Issue 4 (December 2019)

ISSN Print: 2161-4687   ISSN Online: 2161-4695

Google-based Impact Factor: 1.15  Citations  

Mannich-Type Reaction of Aldimines with 2-Silyloxydienes Catalyzed by Ammonium Chloride

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DOI: 10.4236/ijoc.2019.94014    816 Downloads   1,913 Views  Citations

ABSTRACT

Reaction of imines with 2-silyloxydiene catalyzed by ammonium chloride has been perfectly proceeded under environmentally friendly conditions to give Mannich-type product selectively. The reaction would proceed via Mannich-type mechanism, not cyclization/ring-opening process. Cyclopropanation of the corresponding Mannich-type product gave the precursor of prasugrel skeleton in high yield.

Share and Cite:

Fukumoto, S. , Shigenobu, M. and Ishimaru, K. (2019) Mannich-Type Reaction of Aldimines with 2-Silyloxydienes Catalyzed by Ammonium Chloride. International Journal of Organic Chemistry, 9, 163-173. doi: 10.4236/ijoc.2019.94014.

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