Author(s)

Sanabria Kinski¹, Annunziato Maria Antonieta², Chacon Nicolas², Inatti Alfredo²

¹Department of Nanotechnology of Laboratories Leti S.A.V., Guarenas, Venezuela.
²Department of Research and Development, Laboratories Biocontrolled C.A., Guarenas, Venezuela.

In this trial, a topical formulation of a 1% liposome TH cream was compared to a conventional TH formulation. Permeation was evaluated through a synthetic membrane. The study provided information on the rate of diffusion and percentage of drug release and also compared the penetration dynamics in the layers of the stratum corneum of both formulations. Liposome TH cream was able to deliver the active ingredient to a larger number of SC layers, with a higher amount of drug, which is very promising for the treatment of superficial mycoses.

Antifungal, Franz Diffusion Cell, Tape Striping Method, Liposome, Terbinafine HCl, Drug Carrier Systems, Stratum Corneum

Kinski, S. , Antonieta, A. , Nicolas, C. and Alfredo, I. (2019) Evaluation of the Permeation and Penetration of Two Formulations of Terbinafine Chlorhydrate Incorporated in Liposomes (Cream 1%) vs. a Conventional Formulation (Cream 1%), in an in Vitro-ex Vivo Model. Journal of Biosciences and Medicines, 7, 119-133. doi: 10.4236/jbm.2019.78010.