Author(s)

Ryuhei Yamaguchi^1*, Taihei Kotani², Gaku Tanaka², Simon Tupin¹, Kahar Osman³, Nadia Shaira Shafii³, Ahmad Zahran Md Khudzari³, Kazuhiro Watanabe⁴, Hitomi Anzai¹, Atsushi Saito⁵, Makoto Ohta¹

¹Institute of Fluid Science, Tohoku University, Miyagi, Japan.
²Graduate School of Engineering, Chiba University, Chiba, Japan.
³School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
⁴Graduate School of Biomedical Engineering, Tohoku University, Miyagi, Japan.
⁵Department of Neurosurgery, Sendai Medical Center, Miyagi, Japan.

The behavior of wall shear stress (WSS) was previously reported in a deformable aneurysm model using fluid-structure interactions. However, these findings have not been validated. In the present study, we examined the effect of elasticity (i.e., deformation) on wall shear stress inside a cerebral aneurysm at the apex of a bifurcation using particle image velocimetry in vitro. The flow model simulated a human patient-specific aneurysm at the apex of the bifurcation of the middle cerebral artery. Flow characteristics by wall elasticity were examined for both elastic and non-deformable aneurysm models with pulsatile blood flow. The absolute temporally- and spatially-averaged WSS along the bleb wall was smaller in the elastic model than that in the non-deformable model. This small WSS may be related to attenuation of the WSS. Further, the WSS gradient had a finite value near the stagnation point of the aneurysm dome. Finally, the WSS gradient near the stagnation point was slightly smaller in the elastic model than that in the non-deformable model. These data suggest that elasticity of the aneurysm wall can affect the progression and rupture of aneurysms via hemodynamic stress.

Cerebral Aneurysm, Elasticity, Particle Image Velocimetry, Wall Shear Stress

Yamaguchi, R. , Kotani, T. , Tanaka, G. , Tupin, S. , Osman, K. , Shafii, N. , Khudzari, A. , Watanabe, K. , Anzai, H. , Saito, A. and Ohta, M. (2019) Effects of Elasticity on Wall Shear Stress in Patient-Specific Aneurysm of Cerebral Artery. Journal of Flow Control, Measurement & Visualization, 7, 73-86. doi: 10.4236/jfcmv.2019.72006.