Author(s)

Anita Kumari^1*, Parveen Kumar Sharma², Dinesh Kansal³, Rekha Bansal⁴, Rajan Negi²

¹Department of Pharmacology, Dr. YSP Government Medical College, Nahan (HP), India.
²Department of Pharmacology, SLBS Government Medical College, Mandi at Nerchowk (HP), India.
³Department of Pharmacology, Dr. RP Government Medical College, Kangra at Tanda (HP), India.
⁴Department of Pulmonary Medicine, Dr. RP Government Medical College, Kangra at Tanda (HP), India.

Introduction: The adverse drug events (ADEs) to second-line anti-TB drugs are one of the major reasons for the patients default on treatment. A general awareness of various adverse drug events (ADE) and their management is essential for the effective management of tuberculosis. Identification of adverse drug reaction profile of patients can be useful for the early detection, management and prevention of adverse drug events. Material and methods: It was a prospective observational study conducted after approved Institutional Ethics Committee. A total of 104 drug resistant tuberculosis patients registered from 1^st November 2012 to 31st October 2013 started with second line anti-tubercular drugs under PMDT-RNCP after taking written informed consent. Adverse drug reaction during treatment recorded and assessed by Hart wig and WHO scale. Results: 87% patients experienced adverse drug reactions. Total 346 ADR were reported. Most common were gastritis (65%) and arthralgia (60.6%), others were nausea (35.6%), vomiting (32.7%), hyperuricemia (30.8%), giddiness (27%), anorexia (17.3), generalized weakness (15.4), insomnia (10.6%), psychosis (8.6%), hearing impairment (6.7%), hypersensitivity reaction (5.8%), peripheral neuropathy (4.8%), visual disturbance (3.8%), nephrotoxicity (2.9%), forgetfulness (2.9%), gynaecomastia (1.9%), hypothyroidism (1%), seizure (1%), and thrombocytopenia (1%). Conclusion: Majority of patients experienced wide range adverse drug reactions. Most of patients faced the problem within 2 - 3 months of initiation of treatment and managed by symptomatic. Early identification, prompt management and standardized reporting adverse drug reactions at all the level of healthcare are needed.

Drug Resistant Tuberculosis, ADR: Second line Anti-Tubercular Drugs

Kumari, A., Sharma, P.K., Kansal, D., Bansal, R. and Negi, R. (2018) Adverse Drug Reactions in Patients on Second Line Anti-Tubercular Drugs for Drug Resistant Tuberculosis in Rural Tertiary Care Hospital in North India. Journal of Tuberculosis Research, 6, 207-214. doi: 10.4236/jtr.2018.63019.