Journal of Biosciences and Medicines

Volume 6, Issue 5 (May 2018)

ISSN Print: 2327-5081   ISSN Online: 2327-509X

Google-based Impact Factor: 0.51  Citations  

The Expression of E-Cadherin and Vimentin in Non-Small-Cell Lung Cancer and Their Correlation with Epithelial-Mesenchymal Transition (EMT)

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DOI: 10.4236/jbm.2018.65001    1,055 Downloads   2,488 Views  
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ABSTRACT

To investigate the expression of E-cadherin and Vimentin protein in non-small-cell lung cancer (NSCLC) and to analyze the relationship between their expression and epithelial-mesenchymal transition (EMT). Immuno-chemical staining with SP method was conducted to detect the protein expression of E-cadherin and Vimentin in 44 lung cancer tissues. E-cadherin was highly expressed in all normal lung tissues, and Vimentin was lowly expressed in all normal lung tissues. The expression rate of E-cadherin and Vimentin was 40.9% and 25.0% in NSCLC cases. The expressions of E-cadherin and Vimentin were not associated with gender, age, histopathological grading, lymphatic metastasis or smoking status (P > 0.05). But they were associated with clinical stage (P < 0.05). In addition, a negative correlation between the E–cadherin and Vimentin was observed (Spearman’s r = ?0.397, p < 0.05). E-cadherin and Vimentin are involved in the transformation of epithelial cells into the mesenchymal cells, which play important role in the metastasis of lung cancer.

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Tian, M. and Li, Y. (2018) The Expression of E-Cadherin and Vimentin in Non-Small-Cell Lung Cancer and Their Correlation with Epithelial-Mesenchymal Transition (EMT). Journal of Biosciences and Medicines, 6, 1-8. doi: 10.4236/jbm.2018.65001.

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