Author(s)

Ana Paula S. Immich¹, José Antonio Tornero¹, Francesc Cano Casas¹, Manuel J. Lis Arias²

¹Institut d’Investigació Tèxtil i Cooperació Industrial de Terrassa, Universitat Politècnica de Catalunya, Terrassa, Spain.
²Chemical Engineering Department, Universitat Politècnica de Catalunya, Terrassa, Spain.

One of the great advantages of electrospun fibers is the large tridimensional area produced, capable of storing any type of material. The aim of our investigation is to study the electrospinning technique to produce polymer membranes for drug delivery applications, given their large surface area and ability to transport a bioactive compound. A mathematical modeling of the delivery system kinetics was also studied to find the mechanism that controls the releasing process. Results showed that electrospinning could provide regular and smooth membranes suitable for drug delivery processes. The mathematical modeling also proved that thicker PLLA membranes exhibited a Fickian diffusion behavior during the drug transport, presenting better control in drug delivery processes.

Diffusion, Polymer, Nano Escale, Kinetics

Immich, A. , Tornero, J. , Casas, F. and Arias, M. (2017) Electrospun PLLA Membranes for Caffeine Delivery: Diffusional Approach. Journal of Biomedical Science and Engineering, 10, 563-574. doi: 10.4236/jbise.2017.1012042.