Author(s)

Sergio Conte¹, Fang Wang², Nicoletta Sala³, Francesco Losito Casciaro^1,4, Franco Orsucci⁵, Giuseppe Serafini⁶, Ferda Kaleagasioglu^1,7, Leonardo Mendolicchio^1,8, Rich Norman¹, Elio Conte¹

¹School of Advanced International Studies on Applied Theoretical and Non Linear Methodologies of Physics, Bari, Italy.
²College of Science/Agricultural Mathematical Modeling and Data Processing Center, Hunan Agricultural University, Changsha, China.
³University of Lugano, ISSI/Cerfim, Lugano, Swizerland.
⁴Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy.
⁵Division of Psychology, University College, London, England.
⁶Tor Vergata University, Rome, Italy.
⁷Faculty of Medicine, Near East University, North Nicosia, Turkish Republic of Northern Cyprus.
⁸Clinic Villa Miralago, ASL Varese, Italy.

We have investigated the Nu Calm Transcutaneous Vagus Nerve Stimulation device of the NuCalm Solace Lifesciences founding that it gives a multifractal output. A diminishing fractal/multifractal HRV is consistently reported in literature as related to a serious Autonomic Nervous System (ANS) dysfunction that of course we observe in several psychological and psychiatric disorders. Therefore, we suggest the investigators to apply such a device in subjects affected from anxiety, depression and stress using the method of inducing tVNS stimulation.

Depression, Anxiety, Stress, Transcutaneous Vagus Nerve Stimulation, Neuromodulation, Heart Rate Variablity, Multifractals

Conte, S. , Wang, F. , Sala, N. , Casciaro, F. , Orsucci, F. , Serafini, G. , Kaleagasioglu, F. , Mendolicchio, L. , Norman, R. and Conte, E. (2017) The Transcutaneous Vagus Nerve Stimulation Output of the NuCalm Device of Solace Lifesciences Is Found to Be a Multifractal and Therefore It Is Indicated in the Treatment of Heart Rate Variability in the Dysfunction of Autonomic Nervous System in Anxiety, Depression and Stress. Journal of Behavioral and Brain Science, 7, 532-543. doi: 10.4236/jbbs.2017.711038.