Author(s)

Masoumeh Mehrabi^1,2, Asadollah Farhadi^3*, Alireza Kiassat⁴

¹Department of Chemistry, Khouzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran.
²Departmant of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.
³Faculty of Science, Petroleum University of Technology, Ahvaz, Iran.
⁴Chemistry Department, College of Science, Shahid Chamran University, Ahvaz, Iran.

A protocol for the synthesis of some 4-Aryl-1,3,4,6,7,8-hexahydroquinazolin-2,5(1H,6H)-diones (HHQs) was developed by means of a three-component condensation reaction of an aromatic aldehyde, 1,3-cylohexadione and urea in the presence of K₃AlF₆ (Al₂O₃/KF) as catalyst. This reaction is carried out under different conditions including 1) solvent free; 2) reflux in acetonitrile; 3) reflux in ethanol; 4) reflux in chloroform; and 5) reflux in water. In all conditions, the desired products are obtained in high yields after relatively short reaction times. Nevertheless, the reactions proceed faster and in higher yields when they were carried out in acetonitrile. This adopted protocol for some Biginelli-type products has offered the advantages of reusability of the catalyst, high yields and ease of separation of pure products. Furthermore, the catalyst is easily prepared, stabilized and efficiently used under reaction conditions.

4-Aryl-1, 3, 4, 6, 7, 8-Hexahydroquinazolin-2, 5(1H, 6H)-Diones (HHQs), K₃AlF₆(Al₂O₃/KF), 1, 3-Cylohexadione, Acetonitrile

Mehrabi, M. , Farhadi, A. and Kiassat, A. (2017) Synthesis of Some Hexahydroquinazolinones Using K₃AlF₆(Al₂O₃/KF) as an Efficient Catalyst in Some Hexahydroquinazolinone Derivatives. International Journal of Organic Chemistry, 7, 240-253. doi: 10.4236/ijoc.2017.73018.