Dyslipidemia in Kuwaiti Adolescents with Type 1 Diabetes ()
Affiliation(s)
1Department of Surgery, Faculty of Medicine, Kuwait University, Kuwait.
2Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait.
3Department of Medicine, Mubarak AlKabeer Hospital, Ministry of Health, Kuwait.
4Department of Medicine, Farwanyah Hospital, Ministry of Health, Kuwait.
ABSTRACT
Objective: Type 1 diabetes mellitus (T1D) and dyslipidemia (DLP) increase
the risk of cardiovascular disease (CVD). The objective of this study was to
evaluate the progress and perspective of dyslipidemia in young T1D patients . Materials and Methods: The study was cross-sectional and descriptive design.
Medical records of T1D patients were followed at an endocrinology service
from 2008-2014. The collected data included gender, age, duration of
T1D, body mass index (BMI), glycated hemoglobin (HbA1c), total cholesterol
(TC), HDL, LDL and triglycerides (TG). Results: 126 T1D patients were recruited:
69 male (54.8%) and 57 female (45.2%) with a mean of age 16.4
(±0.18) and 16.5 (±0.18), respectively. Diabetes duration and baseline HbA1c
were 14.82 (±2.11) and 8.68 (±1.21), respectively. The HbA1c (average range
of HbA1c 6.5% to 10.7%) increased significantly while following five years by
2.9% (p < 0.001). The prevalence of overweight and obese teens was increasing
from the 1st year to the following five years later. In contrast, the underweight
and healthy subjects were decreasing for the same subsequent years. Means of
HbA1c were significantly higher among overweight and obese categories
throughout following years. All lipid profile revealed significant increase during
five years follow-up study. The prevalence of risk TC/HDL ratio (< 4.1)
gradually raised in the last year follow-up by 52.1% comparing to the baseline
risk ratio (0.8%). The study of TC/HDL ratio with BMI categories revealed
that average T1D patients had an ideal ratio (n = 97) in the 1st year measurement.
After five years follow-up study, the frequency of ideal ratio declined
among all categories in the same rate. Risk TC/HDL ratio in the last year of
the study showed that average group had more risk ratio measurements (n =
47) in contrast to the 1st year measurement (n = 1). The significant positive
correlations were reported between HbA1c and DLP as shown in figure (r2 =
0.85). HbA1c and BMI percentile analyses during long follow-up years werevery highly significant differences (p < 0.0001) between the categories BMI in
each year and from one year to another. Conclusion: Attention must be given
to control DLP and other comorbidities among T1D adolescents to decrease
diabetes macrovascular and microvascular complications.
Share and Cite:
Otaibi, F. , Abdul-Rasool, M. , Yaiesh, R. and Otaibi, N. (2017) Dyslipidemia in Kuwaiti Adolescents with Type 1 Diabetes.
Journal of Diabetes Mellitus,
7, 96-107. doi:
10.4236/jdm.2017.73008.