Author(s)

Arunkanth Krishnakumar Nair^1*, Peddakotla Venkata Ramana¹, P. Venkat Bhaskar Rao¹, Bapatu Hanimi Reddy², Hari Kishan Reddy Ganthi¹, Useni Reddy Mallu¹

¹Sri Krishnadevaraya University, Anantapur, India.
²Jawaharlal Nehru Technological University, Hyderabad, India.

The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer concentrations were optimized adopting the statistical tool, design of experiments (DoE). The optimized formulation of present study exhibited desired controlled drug release characteristics in the alkaline pH conditions and at acidic environment the drug dissolution was minimal as intended.

Atorvastatin Calcium Tablets, Controlled Release, Carbomer, Release Controlling Polymer, Gelling Agent, Povidone

Nair, A. , Ramana, P. , Rao, P. , Reddy, B. , Ganthi, H. and Mallu, U. (2017) Carobomer Based Controlled Release Designs of Atorvastatin Calcium Tablets Evaluated Using Quality by Design (QbD) Approach. American Journal of Analytical Chemistry, 8, 189-209. doi: 10.4236/ajac.2017.83016.