Journal of Diabetes Mellitus

Volume 1, Issue 3 (August 2011)

ISSN Print: 2160-5831   ISSN Online: 2160-5858

Google-based Impact Factor: 0.65  Citations  

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

HTML  Download Download as PDF (Size: 275KB)  PP. 46-53  
DOI: 10.4236/jdm.2011.13007    7,469 Downloads   15,018 Views  Citations

Affiliation(s)

.

ABSTRACT

The long-term effects of Nigella sativa L. oil on some physiological parameters were investigated in normal and streptozotocin (STZ)-induced diabetic male Wistar rats. STZ-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides, cholesterol, low density lipoprotein (LDL-cholesterol), uric acid, urea, creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) while high density lipoprotein (HDL-cholesterol) and total protein levels were significantly decreased compared to normal rats. Administration of black seed oil to diabetic rats resulted in a significant decrease in blood glucose, triglycerides, cholesterol, LDL–cholesterol ALT, AST and uric acid while HDL–cholesterol level was markedly increased compared to untreated diabetic rats after seven weeks of treatment. The results of this study indicate that the diet containing the oil of N. sativa improves the examined physiological parameters in STZ-induced diabetic rats especially when it is used for a longer period.

Share and Cite:

Al-Logmani, A. and Zari, T. (2011) Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats. Journal of Diabetes Mellitus, 1, 46-53. doi: 10.4236/jdm.2011.13007.

Cited by

[1] Phytochemical Constituents 6 and Antidiabetic Features of Black Cumin (Nigella sativa L.)
… Plants and Herbal …, 2024
[2] Role of Bone Marrow-Derived Mononuclear Stem Cells versus Nigella Sativa Oil on Jejunal Alterations in Diabetic Adult Male Albino Rats
Moneam, HH Hussein, MM El-Fark… - Zagazig University …, 2024
[3] Sodium Nitrite Effects on Some Blood and Biochemical Parameters in Glutathione Treated Male Rats
Basrah Journal of Veterinary Research, 2024
[4] The antihyperglycemic effect of LUPINES (termis)‎ in alloxan-induced diabetic rats.
Al-Azhar Journal of Agricultural Research, 2023
[5] A Review of the Potential Health Benefits of Nigella sativa on Obesity and Its Associated Complications
Plants, 2023
[6] Common applications of black cumin Seed (Nigella sativa) oil in folk medicine
Journal of Advanced Pharmacy …, 2023
[7] Assessment of hepatoprotective and antidyslipidemic activities of phenolic leaf extract of vitex doniana on alloxan-induced diabetic rats
International Journal of …, 2023
[8] Hypoglycemic and Hypotensive Effects of Calycotome villosa Subsp. intermedia Seeds in Meriones shawi Rats: In Vivo, Ex Vivo, and In Vitro Investigations
Tangi… - Evidence-Based …, 2023
[9] Black Seed Oil Improves Beef Fat-induced Blood-biochemical Abnormalities in Swiss Albino Mice
Asian Journal of Dairy …, 2023
[10] Guesstimate of thymoquinone diversity in Nigella sativa L. genotypes and elite varieties collected from Indian states using HPTLC technique
Open Life …, 2023
[11] Synthesis and Study the Effect of Pyrimidine Derivative on Renal Function in Female Rats with Diabetes
Masoudi, AA AL-Rikaby, 2022
[12] Green NP‐HPTLC and green RP‐HPTLC methods for the determination of thymoquinone: A contrast of validation parameters and greenness assessment
Phytochemical …, 2022
[13] Nigella sativa in controlling Type 2 diabetes, cardiovascular, and rheumatoid arthritis diseases: Molecular aspects
2021
[14] Solubility Determination, Hansen Solubility Parameters and Thermodynamic Evaluation of Thymoquinone in (Isopropanol+ Water) Compositions
2021
[15] Growth performance, hematological parameters and lipid profile of mice treated with black seed oil and vitamin-E
Asian Journal of …, 2021
[16] The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: A crossover, double-blind …
2021
[17] Growth performance, hematological parameters and lipid profile of mice treated with black seed oil and vitamin-E.
2021
[18] Md. Kamrul Islam Department of Physiology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh* Corresponding …
Asian J. Med. Biol …, 2021
[19] Comparative effects of Glibenclamide and Nigella sativa on aortic contractile and dilation response in diabetic rat
2020
[20] The Perception and Awareness Level about the Risk Factors of Gout among the Indigenous Adult Population of Northern Border Province, Saudi Arabia
P J M H S, 2020
[21] Protective effect of some natural products on acrylamide induced toxicity
2020
[22] Antidiabetic potential of Nigella sativa L seed oil in alloxaninduced diabetic rabbits
2020
[23] Effect of antioxidant-rich propolis and bee pollen extracts against D-glucose induced type 2 diabetes in rats
2020
[24] Effects of Nigella sativa on endothelial dysfunction in diabetes mellitus: A review
2020
[25] Ameliorating effects of black seed oil on bisphenol-A induced abnormality of blood, hormone profile and gonadal histology of female mice
2020
[26] Effect of Nigella sativa Oil on Female Rats Exposed to Lead
Massari, IMA Zeid, I Ullah, 2020
[27] Pharmaceutical Significance of Nigella Sativa L., a Wonder Herb
2020
[28] اثرات هیستوپاتولوژیکی تجویزخوراکی عصار هی هیدرو الکلی سیاه دانه در دستگاه گوارش موش صحرایی.‎
2020
[29] Effects of Nigella Sativa and Allium Sativum on some Physiological Parameters in Normal and Diabetic Rats
2019
[30] The efficacy of Nigella Sativa L extracts to reduce cardiovascular disease risk in diabetic dyslipidemia
2019
[31] EVALUATION OF THE HISTOPATHOLOGICAL AND BIOCHEMICAL EFFECT OF ALOE VERA AQUEOUS EXTRACT ON DIABETES MELLITUS INDUCED BY …
2019
[32] The possible protective effects of virgin olive oil and Nigella Sativa seeds on the biochemical and histopathological changes in pancreas of hyperlipidemic rats
2019
[33] Effect of aquatic and alcoholic extracts Nigella sativa seeds on liver and kidney functions and efficacy in the blood of males albino rats
2018
[34] Solubility, solubility parameters and solution thermodynamics of thymoquinone in different mono solvents
Journal of Molecular Liquids, 2018
[35] Effects of Caralluma russeliana stem extract on some physiological parameters in streptozotocin-induced diabetic male rats
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2018
[36] The Histological Effect of Aqueous Ginger Extract on Kidneys and Lungs of Diabetic Rats
2018
[37] Influence of Olea oleaster Leaves Extract on Some Physiological Parameters in Streptozotocin-Induced Diabetic Rats
2018
[38] EFFECT OF MORINGA OLEIFERA, HORDEUMVU COMPLICATIONS
2018
[39] Antioxidant, immunostimulant and renal protective activities of tri-herbal combination in African Sharptooth Catfish, Clarias gariepinus
2018
[40] Właściwości prozdrowotne czarnuszki siewnej i jej znaczenie w leczeniu dny moczanowej
Forum Zaburzeń Metabolicznych, 2018
[41] Research Article The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats
Seeni, 2017
[42] Comparative Effect of Camel Milk and Black Seed Oil in Induced Diabetic Female Albino Rats.
2017
[43] Hyperlipidemia and associated risk factors: synthetic drugs or medicinal plants? An important question
2017
[44] ALLEVIATION OF LEAD ACETATE-INDUCED TESTICULAR DYSFUNCTION AND RELATED TOXICITY CHANGES IN RATS USING Nigella sativa L. SEEDS
2017
[45] Comparison of Efficacy of Metformin against Flaxseeds and Nigella Sativa in Type 2 Diabetes
2017
[46] Dissolution of inorganic phosphorous ion from teeth treated with different concentrations of aqueous extract of Nigella sativa (Black Seed) in comparison with …
2017
[47] Effect of Different Low Protein Diets Supplemented with Vitamin E, Nigella Sativa Seeds, and Green Tea on Renal Functions among Rats
J. Saudi Soc. for Food and Nutrition., 2017
[48] Hepatoprotective effects of combination hydroalcoholic extracts of Nigella sativa and Curcuma longa on adriamycin-induced oxidative stress in rat
Journal of reports in …, 2017
[49] Thymoquinone Improves Anti-Diabetic Activity of Metformin in Streptozotocin-Induced Diabetic Male Rats
2017
[50] Effects of Thymoquinone Supplementation on Somatostatin Secretion in Pancreas Tissue of Rats
2017
[51] The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats
Evidence-Based Complementary and Alternative Medicine, 2017
[52] Comparative Effect of Camel Milk and Black Seed Oil in Induced Diabetic Female Albino Rats
Pakistan Veterinary Journal, 2017
[53] HepatoprotectiveEffects of Combination Hydroalcoholic Extracts of Nigella Sativa and Curcuma Longa on Adriamycin-Induced Oxidative Stress in Rat
2017
[54] In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa
Evidence-Based Complementary and Alternative Medicine, 2017
[55] The antioxidant, antidiabetic and antilipidemic activity of Salvadora persica twig in alloxan diabetic male rats
2017
[56] Analytical profile of anti-diabetic constituents-Thymoquinone from seed of Nigella Sativa
2017
[57] Effect of Foliar Nutrition on Nigella sativa L. Plants Cultivated under Ammonium Sulfate Treatments
International Journal of Botany, 2016
[58] The effects of aqueous ginger extract on pancreas histology and on blood glucose in normal and alloxan monohydrate-induced diabetic rats.
Biomedical Research, 2016
[59] Hypoglycemic and Hypolipidemic Potential of Nigella sativa L. Seed Extract in Streptozotocin (STZ)-Induced Diabetic Rats
2016
[60] The Various Effects of Nigella Sativa on Multiple Body Systems in Human and Animals
Pertanika Journal of Scholarly Research Reviews, 2016
[61] Effects of Medicinal Plants on Some Physiological Parameters in Rats
2016
[62] The effects of aqueous ginger extract on pancreas histology and on blood glucose in normal and alloxan monohydrate-induced diabetic rats
2016
[63] EFFECTS OF CLOVE OIL ON BLOOD GLUCOSE LEVEL, LIPID PROFILE, LIPID PEROXIDATION, AND KIDNEY FUNCTION ON DIABETIC RATS
2016
[64] Hypoglycemic and Hypolipidemic Potential of Nigella sativa L
2015
[65] Effect of Nigella Sativa Seed Powder on Testosterone and LH levels in Sterptozotocine Induced Diabetes male Albino Rats.
2015
[66] The protective role of alcoholic extract of (Anethum graveolens) seeds on renal function in alloxan induced diabetic rabbits: Weam A. Shakir and Luma W. Khalil
The Iraqi Journal of Veterinary Medicine, 2015
[67] Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded …
2015
[68] The protective role of alcoholic extract of (Anethum graveolens) seeds on renal function in alloxan induced diabetic rabbits
The Iraqi Journal of Veterinary Medicine, 2015
[69] Effect of Nigella Sativa Seed Powder on Testosterone and LH levels in Sterptozotocine Induced Diabetes male Albino Rats
Journal of Pharmaceutical Sciences and Research, 2015
[70] Dissolution of Inorganic Phosphorous Ion from Teeth Treated with Different Concentrations of Aqueous Extract of Nigella Sativa (Black Seed) in Comparison with Sodium Fluoride: An in Vitro Study
2015
[71] NIGELLA SATIVA AND ITS ACTIVE CONSTITUENTS THYMOQUINONE SHOWS PIVOTAL ROLE IN THE DISEASES PREVENTION AND TREATMENT
Asian Journal of Pharmaceutical and Clinical Research, 2015
[72] Nigella sativa Improves Glycemic Control and Ameliorates Oxidative Stress in Patients with Type 2 Diabetes Mellitus: Placebo Controlled Participant Blinded Clinical Trial
PloS one, 2015
[73] Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial
Food & Function, 2015
[74] Formulasi Emulsi Tipe M/A Minyak Biji Jinten Hitam (Nigella sativa L.)
2015
[75] Antidiabetic Efficacy of Nigella sativa Linn. in Alloxan-induced Diabetic Rabbits
The International Medical Journal of Malaysia, 2014
[76] A STUDY TO COMPARE THE HEPATOPROTECTIVE ROLE OF NIGELLA SATIVA AQUEOUS SOLUTION AND OIL SUSPENSION FOLLOWING ACETAMINOPHEN INDUCED HEPATOTOXICITY IN LAYER CHICKS
World Journal of Pharmaceutical Research (WJPR), 2014
[77] Hepatotoxic and Antidiabetic Potentials of Aqeuous Bark Extracts of Ficus asperifolia on Normal and Alloxan-Induced Diabetic Albino Rats.
Annual Review & Research in Biology, 2014
[78] Biochemical Efficacy of Nigella Sativa Oil and Metformin on Induced Diabetic Male Rats
American Journal of Animal and Veterinary Sciences, 2014
[79] The Effects of 8-week Nigella sativa Supplementation and Aerobic Training on Lipid Profile and VO2 max in Sedentary Overweight Females
International journal of preventive medicine, 2014
[80] Effect Of Zea Mays On Glycation End Products
2014
[81] A STUDY TO COMPARE THE HEPATOPROTECTIVE ROLE OF NIGELLA SATIVA AQUEOUS SOLUTION AND OIL SUSPENSION FOLLOWING …
2014
[82] Effects of Nigella sativa (Black Seed) on Serum Levels of Urea and Uric Acid in Acetaminophen Induced Hepatotoxicity of Commercial Layer Chickens
Journal of World’s Poultry Research, 2013
[83] Antidiabetic and Toxicity Evauation of Aqueous Stem Extract of Ficus asperifolia in Normal and Alloxan-Induced Diabetic Albino Rats
2012
[84] Türkiyede yetiştirilen çörek otu (Nigella sativa L.) tohumlarına ön uygulama (priming) ve biyoteknolojik yöntemler uygulayarak, standardize çörek otu yağının elde …
[85] Efek pemberian ekstrak nigella sativa terhadap glukosa darah, AST, dan ALT pada tikus diabetes mellitus yang diinduksi streptozotocin 2016
[86] Efficacy of Nigella sativa extract on abnormalities of cryopreserved sperm of Holstein bulls raised in Iraq

Copyright © 2025 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.