Author(s)

Hongwu Wen^1*, Tongyu Liu², Zhaoyi Feng¹, Weiping Huang³, Ke Ma⁴, Xia Tao¹

¹Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
²Department of Gynecology, Fujian Provincial Tumor Hospital, Fuzhou, China.
³Department of Obstetrics and Gynecology, The Fifth Hospital of Shijiazhuang, Shijiazhuang, China.
⁴Department of Obstetrics & Gynecology, Beijing Tsinghua Changgung Hospital Medical Center, Tsinghua University, Beijing, China.

Objective: The objective is to evaluate the effectiveness of chemotherapy as postoperative adjuvant therapy for stage IB-IIB cervical cancer with intermediate-risk factors. Methods: We retrospectively reviewed the medical records of 119 cervical cancer patients with intermediate-risk factors treated with radical hysterectomy and pelvic lymphadenectomy from December 1997 to September 2010. The intermediate-risk factors included bulky tumor (≥4 cm), lymphovascular space invasion, and deep stromal invasion. Sixteen patients did not receive adjuvant therapy (observation group); 73 were treated with chemotherapy (CT group); 30 were treated with adjuvant radiation therapy (RT group). The significance of the clinical parameters, 3- and 5-year overall survival (OS) rates of each group, was analyzed. Results: The 3- and 5-year OS rates between the observation group and adjuvant therapy group (CT plus RT groups) were not statistically different (3-year OS: 100% and 94.4%, respectively; 5-year OS: 100% and 92.3%, respectively; p > 0.05). The 3- and 5-year OS rates between the CT group and RT group were also not statistically different (3-year OS: 93.6% and 96.4%, respectively; 5-year OS: 80.7% and 96.4%, respectively; p < 0.05). Univariate and multivariate analysis of survival indicated that different adjuvant therapies were not independent prognostic indicators for IB-IIB cervical cancer patients with intermediate-risk factors. Conclusions: CT may have equivalent therapeutic effect as RT for stage IB-IIB cervical cancer patients with intermediate-risk factors after radical surgery, and prospective randomized trial is needed to study the effect of CT in these patients.

Cervical Cancer, Chemotherapy, Radiotherapy, Prognosis

Wen, H. , Liu, T. , Feng, Z. , Huang, W. , Ma, K. and Tao, X. (2015) Treatment Results of Adjuvant Chemotherapy after Radical Hysterectomy for Intermediate-Risk Stage IB-IIB Cervical Cancer. Journal of Cancer Therapy, 6, 1075-1082. doi: 10.4236/jct.2015.612117.