Author(s)

Giuseppe Potrick Stefani^1,2*, Giovana Baldissera³, Ramiro Barcos Nunes¹, Thiago Gomes Heck^4,5, Cláudia Ramos Rhoden^2,6

¹Laboratory of Physiology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
²Laboratory of Oxidative Stress and Atmospheric Pollution, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
³Laboratory of Toxicological Genetics, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
⁴Research Group in Physiology, Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI), Ijuí, Brazil.
⁵Postgraduate Program in Integral Attention to Health, Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI), Ijuí, Brazil.
⁶Department of Pharmacologic Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.

The Metabolic Syndrome (MetS) is a complex condition which is characterized by increased risk factor for cardiovascular diseases, such as dyslipidemia, hypertension and central obesity, in addition to increased risk for type 2 diabetes mellitus (T2DM). All of these factors alone have a notable relationship with DNA damage. However, when the risks are combined, the extent for major outcomes being related to DNA damage (cancer), the consequence can be accelerated by the metabolic dysfunction. This article will illustrate the scientific evidence of the role of DNA damage in MetS, as well as discuss the interplay of major risks factors (air pollution, physical inactivity and dietary interventions) in genomic stability.

Metabolic Syndrome, DNA Damage, Diet, Physical Activity, Air Pollution

Stefani, G. , Baldissera, G. , Nunes, R. , Heck, T. and Rhoden, C. (2015) Metabolic Syndrome and DNA Damage: The Interplay of Environmental and Lifestyle Factors in the Development of Metabolic Dysfunction. Open Journal of Endocrine and Metabolic Diseases, 5, 65-76. doi: 10.4236/ojemd.2015.57009.