Author(s)

Korany A. Ali^1*, Mohamed A. Elsayed¹, Eman Ali Ragab²

¹Applied Organic Chemistry Department, National Research Centre, Dokki-Giza, Egypt.
²Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

We have described herein a catalyst-free preparation method of pyridine-2,6-bis(N-alkylthiazoline-2-thiones) (4a-i) by the reaction of primary amines, CS₂, and pyridine-2,6-bis(2-bromo-1,3- dicarbonyl) derivatives (2a-c) in water. Also, we have described a catalyst free, green chemistry protocols to monobromination of pyridine-2,6-bis(2-bromo-1,3-dicarbonyl) derivatives with high yield, using NBS as a brominating agent, that led to eco-friendly isolation and purification proce-dures. Furthermore, we have studied the reactivity of pyridine-2,6-bis(2-bromo-1-methyl-pro- pane-1,3-dione) (2a) towards thiourea to afford 2,6-bis(5-benzoyl-2-aminothiazol-4-yl)pyridine (9).

N-Alkylthiazoline-2-Thiones, Catalyst-Free Reactions, Monobromination, 2, 6-Disubstituted Pyridine

Ali, K. , Elsayed, M. and Ragab, E. (2015) Catalyst Free Synthesis of Pyridine-2,6-bis(2-bromo-propane-1,3-dione) and Pyrdine-2,6-bis(N-arylthiazoline-2-thiones). Green and Sustainable Chemistry, 5, 39-45. doi: 10.4236/gsc.2015.51006.