Journal of Crystallization Process and Technology

Volume 4, Issue 3 (July 2014)

ISSN Print: 2161-7678   ISSN Online: 2161-7686

Citations  

Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1H-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate

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DOI: 10.4236/jcpt.2014.43018    3,811 Downloads   4,905 Views  Citations

ABSTRACT

An important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.

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Liu, Y. , Tian, G. , Ge, H. , Cao, X. , Hu, D. and Zhang, D. (2014) Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1H-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate. Journal of Crystallization Process and Technology, 4, 140-144. doi: 10.4236/jcpt.2014.43018.

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