The purpose of the present study was to investigate the relationship between stress and anger of rural and urban adolescents of Chittagong district in Bangladesh. The sample of the study consisted of 120 respondents of whom 60 were male (30 rural and 30 urban) and 60 were female (30 rural and 30 urban). Their age levels were 13 - 19. They were selected purposively from different areas of Chittagong district in Bangladesh. Bengali version of Life Stress Scale (Fahim, 2001) was used to measure life stress and Bengali version of Adolescents Anger Rating Scale (AARS) (Islam & Chowdhury, 2011) was used to measure adolescents’ anger. The obtained data were analyzed by using descriptive statistics, t-test and Pearson product moment correlation. Results revealed that the stress of urban adolescents was greater than rural; the anger of urban adolescents was more than the rural; the stress of female adolescents was more than the male and the anger of female adolescents was more than male. Results also showed that adolescents’ stress was positively correlated (r = .86, p < .01) with their anger.