Author(s)

Yiling Wang, Lei Xue

Department of Neuroscience, Duke University, Durham, NC 27708, USA.
Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science, Shanghai 200092, China.

Understanding the signaling cascade that leads to the rapid memory and cognitive breakdown in Alzheimer’s disease is the key to finding a potential treatment method for the disease. Recently, Larson et al. connect the roles of major proteins implicated in the disease progression and propose targeting of cellular prion protein (PrP^c) as a way of someday rescuing synaptic plasticity in humans with Alzheimer’s, as it has been done on mice.

Alzheimer’s; PrP^c; Aβ; Fyn; Tau; Microtubule

Wang, Y. and Xue, L. (2014) Mapping It out: A Novel Signaling Pathway Linking Aβ-PrP^c-Fyn Complex to Cognitive Impairment in Alzheimer’s Disease. Advances in Alzheimer's Disease, 3, 20-23. doi: 10.4236/aad.2014.31003.