Biomechanical properties of cells play a very important role in regulating cells function. Experimental studies found that when Leukocytes move near the vessel wall, the phenomena such as rolling, jumping and adhesion will appear. Based on the non-linear fluid-structure interaction theory, leukocyte’s tiny jumping mechanism and rolling phenomenon were studied. The results were: 1) The choice of time step of leukocyte had a great influence on the movement of leukocyte. Instead of landing on the bottom of flow chamber, leukocyte jumped to a certain height and then moved periodically toward the bottom of the flow chamber again. Leukocyte had the biggest deformation when jumping; 2) Adhesion and rolling along the bottom of the flow chamber appeared in the process of moving forward, the scrolling speed was greater than that of pure rolling. Leukocytes’ movement in blood vessels was closely related with body physiological and pathological characteristics. The study of dynamic movement of leukocyte provided theoretical basis for clinical medicine.