Synthesis, Characterization, Crystal Studies of (E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl) Acrylaldehyde - Crystal Structure Theory and Applications

CSTA > Vol.2 No.4, December 2013

Crystal Structure Theory and Applications

Volume 2, Issue 4 (December 2013)

ISSN Print: 2169-2491 ISSN Online: 2169-2505

Google-based Impact Factor: 0.64 Citations

Synthesis, Characterization, Crystal Studies of (E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl) Acrylaldehyde ()

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DOI: 10.4236/csta.2013.24020 4,579 Downloads 7,972 Views Citations

Author(s)

Veerendra Kumar A. Kalalbandi, J. Seetharamappa

Affiliation(s)

Department of Chemistry, Karnatak University, Dharwad, India.

ABSTRACT

We have synthesized and developed single crystals of the title compound (E)-3-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl) acrylaldehyde, which is a key intermediate of anti-cholesterol fluvastatin drug. It crystallized under orthorhombic system with a space group Pna2₁. The dihedral angle between the indole mean plane and 4-F-phenyl ring was observed to be 111.5 (3)° in the title molecule. Further, strong hydrogen bonds were not found in the crystal structure.

KEYWORDS

Single Crystal Structure; X-Ray Diffraction; Intermediate of Fluvastatin; Indoles

Share and Cite:

Kalalbandi, V. and Seetharamappa, J. (2013) Synthesis, Characterization, Crystal Studies of (E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl) Acrylaldehyde. Crystal Structure Theory and Applications, 2, 148-154. doi: 10.4236/csta.2013.24020.

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