International Journal of Organic Chemistry

Volume 3, Issue 2 (June 2013)

ISSN Print: 2161-4687   ISSN Online: 2161-4695

Google-based Impact Factor: 1.15  Citations  

Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-d]pyrimidines

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DOI: 10.4236/ijoc.2013.32012    4,925 Downloads   8,858 Views  Citations

ABSTRACT

During the last few years, condensed thienopyrimidine derivatives have received considerable attention. The therapeutic importance of thienopyrimidines prompted us to synthesize some of spiro(benzothieno[2,3-d]pyrimidine-4-one) derivatives. Some of the novel benzothino-pyrimidine derivatives 3a, 9b, 10b, 11a, 11b, and 11c showed considerable potent anti-inflammatory and analgesic activity of superior G.I.T. safety profile in experimental rats in comparing to indomethacin and tramadol as reference drugs.

Share and Cite:

Hafez, H. , Al-Duaij, O. and El-Gazzar, A. (2013) Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-d]pyrimidines. International Journal of Organic Chemistry, 3, 110-118. doi: 10.4236/ijoc.2013.32012.

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