Pharmacology & Pharmacy

Volume 4, Issue 2 (April 2013)

ISSN Print: 2157-9423   ISSN Online: 2157-9431

Google-based Impact Factor: 0.67  Citations  

Down Regulation of MyD88 in Macrophages Treated with Liposomes Composed of Phosphatidylserine

HTML  XML Download Download as PDF (Size: 538KB)  PP. 248-254  
DOI: 10.4236/pp.2013.42035    3,712 Downloads   6,356 Views  Citations

ABSTRACT

We have recently demonstrated that liposomes composed of phosphatidylserine (PS-liposomes) suppressed nitric oxide and inflammatory cytokine productions following LPS stimulation in macrophages. In this study, we examined the effect of PS-liposomes on expressions of TLR-4 and MyD88, which are essential for the signal transduction in LPS stimulation. Expression of MyD88 was suppressed when macrophages were treated with PS-liposomes, but not with liposomes of phosphatidylcholine. No change in TLR-4 expression was observed. MyD88 suppression was restored to the control levels when cells were pre-treated with anti-TGF-β antibody, suggesting that TGF-β plays an important role in down-regulation of MyD88 following PS-liposome treatment.

Share and Cite:

Takasugi, Y. , Kurai, F. , Kazume, I. , Otsuka, M. , Negishi, Y. , Tada, R. and Aramaki, Y. (2013) Down Regulation of MyD88 in Macrophages Treated with Liposomes Composed of Phosphatidylserine. Pharmacology & Pharmacy, 4, 248-254. doi: 10.4236/pp.2013.42035.

Copyright © 2025 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.