International Journal of Organic Chemistry

Volume 2, Issue 1 (March 2012)

ISSN Print: 2161-4687   ISSN Online: 2161-4695

Google-based Impact Factor: 1.15  Citations  

Highly Efficient Synthesis of Novel Fluorine Bearing Quinoline-4-carboxylic Acid and the Related Compounds as Amylolytic Agents

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DOI: 10.4236/ijoc.2012.21009    6,659 Downloads   11,696 Views  Citations

ABSTRACT

Highly efficient syntheses of novel fluorine bearing quinoline-4-carboxylic acids and the related compounds had been achieved from cyclocondensation of 2-amino-5-fluorophenyl glyoxylic acid 1 with benzoyle asetanilides 2 in boiling DMF, to give the target 3. Decarboxylation of 3 produced 6-fluoro-2-phenyl-3-(substituted amino)-keto-quinolines 4, while that reaction underwent refluxing, afforded 7-fluoro-1-(aryl)-3-phenyl-pyrrolo[3,4-c] quinoline-2,9-diones 5. Structure of the products has been established from their elemental and spectral analysis. All targets exhibited a high to moderate activity against some Aspergillus fungi as amylolytic agents.

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S. T. Makki, M. , A. Bakhotmah, D. and M. Abdel-Rahman, R. (2012) Highly Efficient Synthesis of Novel Fluorine Bearing Quinoline-4-carboxylic Acid and the Related Compounds as Amylolytic Agents. International Journal of Organic Chemistry, 2, 49-55. doi: 10.4236/ijoc.2012.21009.

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