Author(s)

Yoshihiro Inoue, Hajime Hamashima

Department of Microbiology, Showa Pharmaceutical University, Machida, Japan.
Laboratory of Bio-Medicinal Pharmacology, Showa Pharmaceutical University, Machida, Japan.

We investigated the effect of silver-loaded zeolite (Ag-Z) on antibacterial activity of some antibiotics against Es-cherichia coli against antibiotics. We treated the bacterial suspension of E. coli by Ag-Z to be the level which the decrease of viable cell count was not observed. Susceptibility test of E. coli treated with Ag-Z was carried out against four antibiotics with different mode of action. Apparent increase in susceptibility was found in the case of rifampicin, not in others. The result suggests that application of Ag-Z to ward environment might give a good outcome at the treatment with rifampicin and at the treatment for pathogenic microbe spread through the air, such as tubercle bacilli.

Silver-Loaded Zeolite; Rifampicin; Reactive Oxygen Species

Inoue, Y. and Hamashima, H. (2012) Effect of Silver-Loaded Zeolite on the Susceptibility of Escherichia Coli Against Antibiotics. Journal of Biomaterials and Nanobiotechnology, 3, 114-117. doi: 10.4236/jbnb.2012.31015.