Author(s)

Dickson Mawusi^1,2*, Muller Makafui Mawusi^2,3, Gideon Kwesi Nakotey⁴

¹School of Basic and Biomedical Sciences, Department of Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.
²Assisted Conception Unit, Airport Women’s Hospital, Accra, Ghana.
³Department of Anatomy, School of Medical Sciences, College of Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
⁴Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.

The quantity and quality of oocytes obtained after egg harvesting or retrieval have been regarded as a variable that influences fertilization and the development of viable embryos, determining the number of good embryos required for embryo transfer to achieve implantation (biochemical and clinical pregnancies), as well as the freezing of remaining embryos for future use. This study determined the effects of AMH on oocyte quantity and quality in response to controlled ovarian stimulation (COS) in women undergoing IVF treatment in Ghana. We performed a cohort prospective study at an IVF center in Ghana. Data analysis was performed according to five AMH ranges: group 1 ≤ 0.3 ng/mL (probably negligible response); Group 2 > 0.3 ≤ 2.19 ng/mL (expected lower response); Group 3 > 2.19 ≤ 4.00 ng/mL (possibly intermediate response); Group 4 > 4.00 and ≤6.79 ng/mL (normal response); and Group 5: ≥ 6.79 ng/mL (high response). The number of metaphase II oocytes obtained in each group was recorded. 426 patients were admitted. The data presented were limited to the first IVF cycles to minimize repeated-measures bias. Eight cycles were cancelled due to poor ovarian response. The remaining 418 retrieval cycles were divided into five subgroups according to AMH categories: group 1 ≤ 0.30 (n = 20), group 2 > 0.30 ≤ 2.19 (n = 132), group 3 > 2.19 ≤ 4.00 (n = 158), group 4 > 4.00 ≤ 6.79 (n = 73), and group 5 ≥ 6.79 (n = 35). AMH is the best ovarian reserve test (ORT) for predicting and individualizing gonadotropin dosing to achieve appropriate ovarian responsiveness and minimize both hyper- and poor-ovarian response. This study also demonstrated that anti-Müllerian hormone is a fairly robust metric for predicting cancellation and the number of oocytes that may be retrieved after stimulation in some Ghanaian women undergoing IVF treatment; however, it is a relatively poor predictor of oocyte quality.

Anti Mullerian Hormone, Fertility Centers Ghana, Women, Oocytes, IVF

Mawusi, D. , Mawusi, M. and Nakotey, G. (2025) Association of Anti-Mullerian Hormone on the Quality of Human Oocytes in Some Patients Accessing in Vitro Fertilization (IVF) Treatment in a Private Fertility Center in Ghana. Advances in Reproductive Sciences, 13, 207-224. doi: 10.4236/arsci.2025.134018.