Author(s)

Zurab Shekiladze, Giorgi Gogiberidze, Davit Zurabashvili, Sofo Chikobava, Davit Natadze, Marine Nikolaishvili

Beritashvili Center of Experimental Biomedicine Radiology Department, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.

Tskaltubo radon-rich mineral water produced a different immunological profile. While similarly effective in suppressing pathogenic flora, this intervention preserved and possibly enhanced the mucosal immune response. In Group 2, patients exhibited increased levels of interferon-gamma (IFN-γ) and interleukin-4 (IL-4), without a corresponding rise in proinflammatory cytokines such as IL-1 or IL-6. This indicates a measured activation of the immune system in response to surgical trauma. Most notably, IL-10 levels increased in this group, suggesting a heightened regulatory response and a more balanced immune environment conducive to controlled healing.

Radon Therapy, Mucosal Immunity, Immune Modulation, Cytokine Response, Postoperative Healing, Dental Implantation, Salivary Biomarkers, Antibiotic Effects, Tissue Regeneration

Shekiladze, Z. , Gogiberidze, G. , Zurabashvili, D. , Chikobava, S. , Natadze, D. and Nikolaishvili, M. (2025) Comparative Response of Immune System Activation in Patients in the Postoperative Period: A Study of Antibacterial Therapy versus Radonized Water from Tskaltubo. Journal of Biosciences and Medicines, 13, 236-242. doi: 10.4236/jbm.2025.137018.