Author(s)

Kenji Niwa^1*, Saki Tsurue¹, Rui Kyogoku², Masanori Isobe³, Yoh Hayasaki³, Sakae Mori⁴, Keigo Kuwabara⁴, Kentaro Niwa⁵, Takuji Tanaka⁶

¹Department of Obstetrics & Gynecology, Gujo City Hospital, Gujo City, Japan.
²Department of Obstetrics & Gynecology, Gifu Prefectural General Medical Center, Gifu City, Japan.
³Department of Obstetrics & Gynecology, University School of Medicine, Gifu City, Japan.
⁴Section of Laboratory Medicine, Gujo City Hospital, Gujo City, Japan.
⁵Department of Obstetrics & Gynecology, Central Japan International Medical Center, Minokamo City, Japan.
⁶Department of Pathology, Chubu Pathology, Gifu, Japan.

LEEP conization with vaporization was performed for 86 CIN2⁺ cases. Our data suggest that combining LEEP conization and vaporization results in a higher estimated cumulative HPV clearance rate than LEEP alone. The clearance rate tended to be better in younger patients. Vaporization could provide a promising therapeutic option for VaIN2 associated with high-risk HPV infection. Treatment of CIN2⁺ and VaIN2 using ball electrode vaporization and LEEP conization appears feasible and effective, even in settings lacking specialized surgical devices. After conservative treatment of CINs or VaIN, HR-HPV persists in some cases even in the NILM state without dysplasia, and long-term follow-up is needed.

HPV, CINs, LEEP Conization, Vaporization, VaIN

Niwa, K. , Tsurue, S. , Kyogoku, R. , Isobe, M. , Hayasaki, Y. , Mori, S. , Kuwabara, K. , Niwa, K. and Tanaka, T. (2025) Follow-Up of HPV Clearance after LEEP Conization and Vaporization for CIN2⁺, and Vaporization for VaIN2. Open Journal of Pathology, 15, 136-149. doi: 10.4236/ojpathology.2025.153013.