Author(s)

Alexander Bukhvostov, Anna Semenova, Olga Kamkina, Stanislav Arkhangelskiy, Dmitry A. Kuznetsov^*

Institute of Biomedicine, N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation.

A novel, fast-n-reliable, Quartz capillary silica zone electrophoresis required to upgrade an arsenal of analytical tools for current pharmacokinetics studies on porphyrin-fullerene nanoparticles has been proposed. The fullerene(C₆₀)-tetra(p-hydroxyphenyl)porphyrin structures, known for their capabilities to paramagnetic ²⁵Mg²⁺ delivery, were found quantitatively detectable in a total rat brain cytosol (S125) fraction, once these nanocationites administered in a single, either 1.0 mg/kg or 20.0 mg/kg, i.v. injection followed by 12 hrs long animal-drug exposition time. Driven by pressing needs in ongoing preclinical trial platform developments, the CZE track proposed might make an impact on both convenience and efficiency of pharmacokinetic estimate of medicinal nanocationites.

Neuroprotectors, Porphyrin-Fullerenes, Ischaemic Brain Stroke, Preclinical Trial, Capillary Zone Electrophoresis (CZE)

Bukhvostov, A. , Semenova, A. , Kamkina, O. , Arkhangelskiy, S. and Kuznetsov, D. (2025) A Novel Capillary Zone Electrophoresis Technique for Pharmacokinetic Studies on Porphyrin-C₆₀ Based Neuroprotectors. Preliminary Report. Pharmacology & Pharmacy, 16, 165-173. doi: 10.4236/pp.2025.166011.