Author(s)

Yameng Yang¹, Min Wang^2*

¹Department of Rheumatology and Immunology, The First Affiliated Hospital of Yangtze University, Jingzhou, China.
²Clinical Medical College, Hubei College of Chinese Medicine, Jingzhou, China.

Objective: To explore the efficacy and safety of knee joint injection of TNF-α antagonist (Yisaipu injection) in patients with rheumatoid arthritis under ultrasound “visualization” guidance. Methods: A total of 240 patients with rheumatoid arthritis from Jingzhou First People’s Hospital were selected as research subjects between May 2024 and May 2025, randomly divided into a control group (120 patients) and an intra-articular injection group (120 patients). The control group received treatment with prednisone tablets 10mg qd + methotrexate 10mg qw; the intra-articular injection group received an additional 25mg TNF-α antagonist (Yisaipu injection) via knee joint puncture under ultrasound guidance. Data on knee joint MSUS ultrasound scores, erythrocyte sedimentation rate, C-reactive protein, and DAS28 score were collected at 0, 3, and 6 months post-treatment for observation of therapeutic effects. Results: After treatment, the knee joint MSUS ultrasound scores, serological indicators, and DAS28 scores in the intra-articular injection group showed significant improvement compared to the control group, with no significant adverse reactions observed. Conclusion: Under ultrasound “visualization” guidance, knee joint injection of TNF-α antagonist in patients with rheumatoid arthritis has significant efficacy and high safety, and musculoskeletal ultrasound assessment can provide effective evidence.

Musculoskeletal Ultrasound, Ultrasound Guidance, Rheumatoid Arthritis, Knee Joint Cavity Injection, TNF-α Antagonist

Yang, Y.M. and Wang, M. (2025) Clinical Efficacy and Safety Evaluation of TNF-α Antagonist Ultrasound-Guided Knee Injection for Rheumatoid Arthritis. Journal of Biosciences and Medicines, 13, 221-230. doi: 10.4236/jbm.2025.135017.