Author(s)

Camila Ponce-Acosta¹, Maria Jose Santa-Ana-Bayona¹, Gilberto H. Acosta-Gutiérrez², Pavel Martinez-Dominguez³, Santiago Luna-Alcala¹, Alfonso Gonzalez-Trejo⁴, Hugo A. Valencia-Hernandez⁵, Enrique C. Guerra⁶, Nilda Espinola-Zavaleta^7,8

¹Mexican Faculty of Medicine, La Salle University, Mexico City, Mexico.
²Institute of Biomedical Sciences, Autonomous University of Ciudad Juarez, Ciudad Juarez, Mexico.
³Faculty of Medicine and Biomedical Science, Autonomous University of Chihuahua, Chihuahua, Mexico.
⁴School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
⁵Faculty of Medicine, Villa Rica University, Veracruz, Mexico.
⁶MD-PhD (PECEM) Program, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
⁷Department of Nuclear Cardiology, National Institute of Cardiology Ignacio Chavez, Mexico City, Mexico.
⁸Department of Echocardiography, ABC Medical Center, Mexico City, Mexico.

Cardiac amyloidosis is a disease characterized by the deposition of misfolded proteins in the myocardium, leading to restrictive cardiomyopathy. It comprises two subtypes: immunoglobulin light chain cardiac amyloidosis (AL) and transthyretin cardiac amyloidosis (ATTR). ATTR is classified as wild-type (wtATTR) and hereditary (hATTR), depending on the presence or absence of a transthyretin (TTR) genetic mutation. The diagnosis of cardiac amyloidosis is challenging due to nonspecific symptoms with other cardiac conditions, often resulting in misdiagnosis. This mini review provides an in-depth analysis of cardiac amyloidosis, focusing on its subtypes, clinical manifestations, diagnostic multimodal imaging, and recent therapeutic advancements.

Amyloid, Echocardiography, Diastolic Dysfunction, Cardiac Infiltration

Ponce-Acosta, C. , Santa-Ana-Bayona, M. , Acosta-Gutiérrez, G. , Martinez-Dominguez, P. , Luna-Alcala, S. , Gonzalez-Trejo, A. , Valencia-Hernandez, H. , Guerra, E. and Espinola-Zavaleta, N. (2025) Diagnosis and Management of Cardiac Amyloidosis: The Role of Multimodal Imaging—A Mini Review. World Journal of Cardiovascular Diseases, 15, 235-253. doi: 10.4236/wjcd.2025.155021.