Author(s)

Yousef Samir Amr¹, Aseel Qassem Al-Omari², Mousa Husein Saadeh³, Samir Sami Amr^2*

¹Department of Internal Medicine, Istishari Hospital, Amman, Jordan.
²Department of Pathology and Laboratory Medicine, Istishari Hospital, Amman, Jordan.
³Department of Radiology, Istishari Hospital, Amman, Jordan.

We report a 63-year-old man who developed massive splenic infarction two months following COVID-19 infection. He presented with high grade fever, weakness, dysuria and chronic productive cough. He was found to have a large splenic infarction involving most of the spleen. We document the course and outcome of his illness, and the histopathological findings of the resected spleen. A discussion of COVID-19 associated hypercoagulability is presented, with a comprehensive review of the literature on splenic infarction associated with COVID-19 infection.

COVID-19, Splenic Infarction, Hyper-Coagulability, Thrombosis

Amr, Y.S., Al-Omari, A.Q., Saadeh, M.H. and Amr, S.S. (2025) Massive Splenic Infarction Following COVID-19 Infection, with Histopathological Observations, and Review of the Literature. Open Journal of Pathology, 15, 69-89. doi: 10.4236/ojpathology.2025.152007.