Author(s)

Qian Zhang, Chengxuan Tian, Yaowei Wang, Wei Wu^*

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi’an Medical University, Xi’an, China.

T-cell immunoglobulin and mucin domain-containing protein-3 (Tim-3), an emerging immune checkpoint molecule, was found to critically regulate the pathogenesis of respiratory disorders, including chronic obstructive pulmonary disease (COPD), bronchial asthma, and bronchogenic carcinoma, through its dynamic expression patterns and genetic polymorphisms. This review synthesized current knowledge on the structural and functional characteristics of Tim-3, delineated its roles in COPD, asthma, and lung cancer, and evaluated its therapeutic potential, thereby offering novel perspectives for targeting Tim-3 in respiratory disease management.

COPD, Tim-3, Asthma, Lung Cancer

Zhang, Q., Tian, C.X., Wang, Y.W. and Wu, W. (2025) Research Progress of T-Cell Immunoglobulin and Mucin Domain-Containing Protein-3 (Tim-3) in Respiratory Diseases. Journal of Biosciences and Medicines, 13, 349-355. doi: 10.4236/jbm.2025.133026.