Author(s)

Yanzhi Wang^1*, Guang Liu², Dongchen Yao³, Xianliang Li⁴, Tianxiang Lei⁵, Tianwen Lei⁶

¹Academic Affairs Office, Binzhou Medical University, Yantai, China.
²Department of Traditional Chinese Medicine, Qufu Hospital of Traditional Chinese Medicine, Jining, China.
³School of Pharmacy, Binzhou College of Science and Technology, Binzhou, China.
⁴School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
⁵Center of Integrated Traditional Chinese and Western Medicine, Qingdao University, Qindao, China.
⁶Department of Gynecology and Obstetrics II, Jinan Zhangqiu District People’s Hospital, Jinan, China.

Aims: To investigate the pathogenesis of sarcopenia and the role of important cytokines TNF-α, IL-6, and IL-15 in patients with sarcopenia by measuring their levels. Methods: During September to December 2020, a total of 200 healthy individuals were randomly selected as research subjects from those who were undergoing physical examinations at Linyi People’s Hospital. These subjects were divided into three groups, with 155 cases in the non-sarcopenia group (Group 1), 25 cases in the pre-sarcopenia group (Group 2), and 20 cases in the sarcopenia group (Group 3). The skeletal muscle content of the limbs was accurately measured using bioelectrical impedance analysis (BIA) technology. The levels of three cytokines TNF-α, IL-6, and IL-15 in the peripheral venous blood serum, which are closely related to skeletal muscle mass, underwent quantitative detection by applying the enzyme-linked immunosorbent assay (ELISA). Results: The IL-15 level in the non-sarcopenia group was significantly higher than that in the sarcopenia group, and the difference was statistically significant (P < 0.05). However, there was no significant statistical difference in the levels of TNF-α and IL-6 among the three groups. Conclusion: IL-15 may play an important role in the occurrence and development of sarcopenia, and its decreased level may be related to the progression of sarcopenia.

Sarcopenia, IL-15, IL-6, TNF-α, Cytokines

Wang, Y.Z., Liu, G., Yao, D.C., Li, X.L., Lei, T.X. and Lei, T.W. (2024) Correlation Study between Serum Cytokines TNF-α, IL-6, IL-15 Levels and Sarcopenia. Open Access Library Journal, 11, 1-6. doi: 10.4236/oalib.1112687.