Author(s)

Evadne Rodriguez¹, Justin Flores², Kathleen Click³, Vivian Li⁴, Alexandra Loperfito⁵, Marissa Ruppe⁶, Kelly Frasier⁷

¹School of Medicine, University of Missouri, Columbia, MO, USA.
²College of Osteopathic Medicine, California Health Sciences University, Clovis, CA, USA.
³College of Osteopathic Medicine, Kansas City University, Kansas City, MO, USA.
⁴Nuvance Health, Vassar Brothers Medical Center, Poughkeepsie, NY, USA.
⁵Edward via College of Osteopathic Medicine, Blacksburg, VA, USA.
⁶Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.
⁷Department of Dermatology, Northwell Health, New Hyde Park, NY, USA.

Skin diseases such as psoriasis, atopic dermatitis, burns, and other barrier insults pose ongoing therapeutic challenges, often requiring treatments that address both inflammation and skin barrier repair. The primary aim of this review is to provide a comprehensive overview of the potential benefits of sea buckthorn oil, derived from Hippophae rhamnoides, as a treatment for various skin diseases, detailing its anti-inflammatory properties, reporting benefits across several skin conditions, and highlighting challenges in formulation as well as preservation of the oil’s nutritional benefits. Drawing from a wide array of existing literature, this review investigates sea buckthorn oil’s rich composition of omega fatty acids, vitamins, and antioxidants, which may contribute to its therapeutic effects by modulating inflammatory pathways and enhancing skin barrier function. Clinical trials and patient case studies indicate that sea buckthorn oil shows promise in reducing erythema, inflammation, and improving skin sensitivity. However, challenges such as formulation stability, sourcing of quality oil, and variability in response to treatment across conditions need to be addressed. Future research should focus on optimizing formulations and conducting large-scale clinical trials to validate the therapeutic efficacy of sea buckthorn oil in the management of skin diseases. Additionally, further exploration of the regulatory mechanisms underlying its ability to modulate inflammation and repair the skin barrier is needed to fully elucidate its clinical potential. Sea buckthorn oil offers a novel and promising adjunctive treatment for psoriasis, atopic dermatitis, and wound-healing with significant potential to enhance therapeutic options for additional skin diseases.

Anti-Inflammatory, Skin Barrier, Sea Buckthorn Oil, Psoriasis, Atopic Dermatitis, Wound-Healing

Rodriguez, E. , Flores, J. , Click, K. , Li, V. , Loperfito, A. , Ruppe, M. and Frasier, K. (2024) Use of Sea Buckthorn Oil in the Treatment of Skin Disease: Anti-Inflammatory Benefits, Clinical Applications, and Formulary Challenges. Journal of Biosciences and Medicines, 12, 271-284. doi: 10.4236/jbm.2024.1212022.