Author(s)

Medyouni Hajar¹, Chouef Jihane¹, Siyouri Oumaima¹, Chbihi Chaymae¹, Saoudi Amira², Amaadour Lamiae¹, Oualla Karima¹, Benbrahim Zineb¹, Arifi Samia¹, Mellas Nawfel¹

¹Medical Oncology Department Chu Hassan II, Fes, Morocco.
²Radiotherapy Department Chu Hassan II, Fes, Morocco.

Retroperitoneal sarcomas (RPS) pose a challenge in treatment due to their rarity and complex nature. This retrospective study aimed to analyze the epidemiological, clinicopathological characteristics, and survival out-comes of RPS patients treated over an 11-year period. Seventeen patients diagnosed with RPS were included, with leiomyosarcoma being the most prevalent subtype. Surgical excision was the primary treatment modality, often complemented by radiotherapy and chemotherapy. The 5-year and 10-year overall survival rates were 56% and 46.9%, respectively, with a median progression-free survival of 10 months. Discussion highlights the importance of complete surgical resection and tumor grade as prognostic indicators. Local recurrence remains a significant concern despite advancements in treatment modalities. The role of radiotherapy in reducing local recurrence risk is acknowledged, particularly in the preoperative set-ting. For metastatic RPS, a multidisciplinary approach integrating surgery and systemic therapy is crucial. Patient selection for surgical interventions considers tumor biology, disease burden, and response to chemotherapy. Chemotherapy, primarily anthracycline-based, remains a cornerstone in managing unresectable or metastatic disease, with emerging agents showing promise in clinical trials. Overall, a tailored treatment approach emphasizing radical resection and adjuvant therapies offers the best chance for long-term survival in RPS patients.

Retroperitoneal Sarcomas (RPS), Multidisciplinary Approach, Chemotherapy, Metastatic Disease

Hajar, M. , Jihane, C. , Oumaima, S. , Chaymae, C. , Amira, S. , Lamiae, A. , Karima, O. , Zineb, B. , Samia, A. and Nawfel, M. (2024) Real-Life Results of a Cohort of Retroperitoneal Sarcomas (RPS): Management at Hassan II University Hospital in Fes. Open Access Library Journal, 11, 1-8. doi: 10.4236/oalib.1111439.